Kathrin  Muegge, M.D.

Kathrin Muegge, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Mouse Cancer Genetics Program


Dr. Muegge studies molecular mechanisms that alter chromatin structure and function during development. She discovered several links between chromatin modifiers, including nucleosome remodeling, histone variants, chromatin accessibility and DNA methylation.

The current focus is to understand how mutations of the chromatin remodeler LSH perturb the process of recombination and DNA repair in the genetic ICF4 syndrome.

Areas of Expertise

Nucleosome Remodeling
Histone Variants
DNA Methylation
Cellular Differentiation
Genome Stability


Selected Key Publications

LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2

Ni K, Muegge K
Nucleic Acids Res. gkab588. doi: 10.1093/nar/gkab588: 2021. [ Journal Article ]

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.

Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, Aladjem MI, Burkett S, Finney R, Ding X, Sharan SK, Muegge K
Nat Commun. 12(1):3520: 2021. [ Journal Article ]

LSH mediates gene repression through macroH2A deposition

Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR, Muegge K
Nat Commun. 11(1):5647: 2020. [ Journal Article ]

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.

He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, Wang C, Sun L, Klarmann K, Keller J, Tubbs A, Nussenzweig A, Muegge K
Proc Natl Acad Sci U S A. 117(33):20100-20108: 2020. [ Journal Article ]

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability.

Kharat SS, Ding X, Swaminathan D, Suresh A, Singh M, Sengodan SK, Burkett S, Marks H, Pamala C, He Y, Fox SD, Buehler EC, Muegge K, Martin SE, Sharan SK
Sci Signal. 18;13(645):eaba8091: 2020. [ Journal Article ]

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Postdoctoral Fellow (Visiting)
Vinayaki Pillai, Ph.D.
Postdoctoral Fellow (Visiting)
Amit Gupta, Ph.D.
Postdoctoral Fellow (Visiting)
Rwitie Mallik , Ph.D.
Postdoctoral Fellow (Visiting)
Priyank Chaturvedi , Ph.D.
Visiting Fellow
Preeti Gupta, Ph.D.


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