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Kathrin  Muegge, M.D.

Kathrin Muegge, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Mouse Cancer Genetics Program

RESEARCH SUMMARY

Dr. Muegge studies molecular mechanisms that alter chromatin structure and function during development. She discovered several links between chromatin modifiers, including nucleosome remodeling, histone variants, chromatin accessibility and DNA methylation.

The current focus is to understand how mutations of the chromatin remodeler LSH perturb the process of recombination and DNA repair in the genetic ICF4 syndrome.

Areas of Expertise

1) nucleosome remodeling 2) histone variants 3) DNA methylation 4) cellular differentiation 5) genome stability 6) murine development

Publications

Selected Key Publications

LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2

Ni K, Muegge K
Nucleic Acids Res. gkab588. doi: 10.1093/nar/gkab588: 2021. [ Journal Article ]

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.

Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, Aladjem MI, Burkett S, Finney R, Ding X, Sharan SK, Muegge K
Nat Commun. 12(1):3520: 2021. [ Journal Article ]

LSH mediates gene repression through macroH2A deposition

Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR, Muegge K
Nat Commun. 11(1):5647: 2020. [ Journal Article ]

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.

He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, Wang C, Sun L, Klarmann K, Keller J, Tubbs A, Nussenzweig A, Muegge K
Proc Natl Acad Sci U S A. 117(33):20100-20108: 2020. [ Journal Article ]

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability.

Kharat SS, Ding X, Swaminathan D, Suresh A, Singh M, Sengodan SK, Burkett S, Marks H, Pamala C, He Y, Fox SD, Buehler EC, Muegge K, Martin SE, Sharan SK
Sci Signal. 18;13(645):eaba8091: 2020. [ Journal Article ]

Job Vacancies

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Team

Postdoctoral Fellow (Visiting)
Minakshi Mann , Ph.D.
Postdoctoral Fellow (Visiting)
Amit Gupta, Ph.D.
Postdoctoral Fellow (Visiting)
Rwitie Mallik , Ph.D.
Postdoctoral Fellow (Visiting)
Priyank Chaturvedi , Ph.D.
Visiting Fellow
Preeti Gupta, Ph.D.