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Kathleen Kelly, Ph.D.

Kathleen Kelly, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
NIH Scientist Emeritus
Genitourinary Malignancies Branch

RESEARCH SUMMARY

Dr. Kelly’s program investigated mechanisms of prostate cancer tumorigenesis and progression. A major area of focus addressed the roles of oncogenotype, tumor heterogeneity/cancer stem cells, and metabolism in the development of therapeutic responses, especially for castrate-resistant prostate cancer. Additional research investigated signal transduction pathways that influenced prostate cancer bone metastasis. As chief of LGCP, Dr. Kelly advanced integration with the clinical prostate cancer program to carry out mechanism-based translational studies using a variety of pathological, genomic, and patient-derived live culture approaches.

Areas of Expertise

Cancer Drug Discovery
Prostate Cancer
Organoid Cultures
Drug Response And Resistance
Cancer Metabolism
Imaging Cancer (Cellular And Clinical)

Publications

Selected Recent Publications

TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence

Fang L, Li D, Yin J, Pan H, Ye H, Bowman J, Capaldo B, Kelly K
Cancer Gene Ther. Apr 7: doi: 10.1038/s41417-022-00454-5, 2022. [ Journal Article ]

EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis

Li L, Ameri AH, Wang S, Jansson KH, Casey OM, Yang Q, Beshiri ML, Fang L, Lake RG, Agarwal S, Alilin AN, Xu W, Yin J, Kelly K
Oncogene. Aug;38(35): 6241-6255, 2017. [ Journal Article ]

A PDX/organoid biobank of advanced prostate cancers captures genomic and phenotypic heterogeneity for disease modeling and therapeutic screening

Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin JJ, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K.
Clinical Cancer Research. Sep 1;24(17): 4332-4345, 2018. [ Journal Article ]

Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration

Ward Y, Lake R, Faraji F, Sperger J, Martin P, Gilliard C, Ku KP, Rodems T, Niles D, Tillman H, Yin J, Hunter K, Sowalsky AG, Lang J, Kelly K.
Cell Reports. 23(3): 808-822, 2018. [ Journal Article ]

Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer

Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K.
Oncogene. 36(4): 525-533, 2017. [ Journal Article ]

Alumni

Margaret White, Ph.D
Margaret White, Ph.D
2017-2023
Postdoctoral Fellow
Neil Alilin
Neil Alilin
2016-2023
Animal Technician (Contr.)
Emily Kolyvas
Emily Kolyvas
2018-2023
Predoctoral Fellow (Medical Student)
Joel Bowman
Joel Bowman
2020-2023
Postbaccalaureate Fellow
Asha Daryanani
Asha Daryanani
2021-2023
Postbaccalaureate Fellow
Michael Beshiri, Ph.D.
Michael Beshiri, Ph.D.
2014-2023
Postdoctoral Fellow
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