Breadcrumb

Kathleen Kelly, Ph.D.

Kathleen Kelly, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Kelly’s program investigates mechanisms of prostate cancer tumorigenesis and progression. A major area of focus addresses the roles of oncogenotype, tumor heterogeneity/cancer stem cells, and metabolism in the development of therapeutic responses, especially for castrate resistant prostate cancer. Additional research investigates signal transduction pathways that influence prostate cancer bone metastasis. As chief of LGCP, Dr. Kelly advances integration with the clinical prostate cancer program to carry out mechanism-based translational studies using a variety of pathological, genomic, and patient-derived live culture approaches.

Areas of Expertise

1) prostate cancer, 2) organoid cultures, 3) drug response and resistance, 4) metabolism and imaging, 5) cancer stem cells, 6) oncogenomes

Publications

Selected Recent Publications

TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence

Fang L, Li D, Yin J, Pan H, Ye H, Bowman J, Capaldo B, Kelly K
Cancer Gene Ther. Apr 7: doi: 10.1038/s41417-022-00454-5, 2022. [ Journal Article ]

EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis

Li L, Ameri AH, Wang S, Jansson KH, Casey OM, Yang Q, Beshiri ML, Fang L, Lake RG, Agarwal S, Alilin AN, Xu W, Yin J, Kelly K
Oncogene. Aug;38(35): 6241-6255, 2017. [ Journal Article ]

A PDX/organoid biobank of advanced prostate cancers captures genomic and phenotypic heterogeneity for disease modeling and therapeutic screening

Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin JJ, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K.
Clinical Cancer Research. Sep 1;24(17): 4332-4345, 2018. [ Journal Article ]

Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration

Ward Y, Lake R, Faraji F, Sperger J, Martin P, Gilliard C, Ku KP, Rodems T, Niles D, Tillman H, Yin J, Hunter K, Sowalsky AG, Lang J, Kelly K.
Cell Reports. 23(3): 808-822, 2018. [ Journal Article ]

Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer

Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K.
Oncogene. 36(4): 525-533, 2017. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (CRTA)
Margaret White, Ph.D.
Postdoctoral Fellow (Visiting)
Sonam Raj, Ph.D.
Predoctoral Fellow (Medical Student)
Emily A. Kolyvas
Animal Technician (Contr.)
Aian Neil Alilin
Postbaccalaureate Fellow (CRTA)
Xavier Moore
Postbaccalaureate Fellow (CRTA)
Joel Bowman
Postbaccalaureate Fellow (CRTA)
Asha Daryanani

Alumni

Remi Adelaiye-Ogala, Ph.D.
Remi Adelaiye-Ogala, Ph.D.
2017-2020
Postdoctoral Fellow
Wardah Bajwa
Wardah Bajwa
2019-2020
Postbaccalaureate Fellow
Danielle Burner
Danielle Burner
2019-2020
Postbaccalaureate Fellow
Keith Jansson, Ph.D.
Keith Jansson, Ph.D.
2013-2020
Postdoctoral Fellow
Lu Fan
Lu Fan
2019-2020
Guest Researcher
Lechen (Frank) Li
Lechen (Frank) Li
2015-2019
Guest Researcher
Morgan Riba
Morgan Riba
2018-2019
Postbaccalaureate Fellow
Julianna Kostas
Julianna Kostas
2018-2019
Postbaccalaureate Fellow
Marisa Reynolds
Marisa Reynolds
2019
Summer Student
Yasmine Abbey
Yasmine Abbey
2016-2018
Postbaccalaureate Fellow
Caitlin Tice
Caitlin Tice
2017-2018
Postbaccalaureate Fellow
Kerry McGowen
Kerry McGowen
2016-2018
Postbaccalaureate Fellow
John Tucker
John Tucker
2016-2017
Postbaccalaureate Fellow
Hong Pan
Hong Pan
2015-2017
Guest Researcher
Simeng Wang
Simeng Wang
2014-2017
Special Volunteer
Yvona Ward, Ph.D.
Yvona Ward, Ph.D.
1997-2016
Staff Scientist
Crystal Tran
Crystal Tran
2015-2016
Postbaccalaureate Fellow
Lauren Stahl
Lauren Stahl
2015-2016
Postbaccalaureate Fellow
Heather Tillman, DVM, Ph.D.
Heather Tillman, DVM, Ph.D.
2008-2015
Postdoctoral Fellow
Caitlyn Fuller
Caitlyn Fuller
2014-2015
Postbaccalaureate Fellow
Jessica Snyder
Jessica Snyder
2014-2015
Animal Technician (Contr.)
Paul Hynes, Ph.D.
Paul Hynes, Ph.D.
2008-2014
Visiting Fellow
Dongmei Li
Dongmei Li
2013-2014
Special Volunteer
Amir Ameri
Amir Ameri
2013-2014
Postbaccalaureate Fellow
Vivian Xu
Vivian Xu
2014
Summer Student
Orla Casey, Ph.D.
Orla Casey, Ph.D.
2006-2013
Visiting Fellow
Yen-Nien Liu, Ph.D.
Yen-Nien Liu, Ph.D.
2009-2013
Postdoctoral Fellow
Jake Cawley
Jake Cawley
2012-2013
Medical Research Scholar
Benjamin Barrett
Benjamin Barrett
2011-2013
Postbaccalaureate Fellow
Derek Brown
Derek Brown
2013
Summer Student
Kamilia Zerrouki
Kamilia Zerrouki
2013
Special Volunteer
Wassim Abou Kheir, Ph.D.
Wassim Abou Kheir, Ph.D.
2007-2011
Postdoctoral Fellow
Victoria Seng
Victoria Seng
2009-2011
Postbaccalaureate Fellow
Philip Martin, DVM, Ph.D.
Philip Martin, DVM, Ph.D.
2005-2009
Postdoctoral Fellow
Luhua Zhang
Luhua Zhang
2007-2009
Postbaccalaureate Fellow
Rachel Pierce
Rachel Pierce
2006-2008
Postbaccalaureate Fellow