Karlyne M. Reilly, Ph.D.

Karlyne M. Reilly, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Reilly received her Ph.D. in molecular and cellular biology from Harvard University and trained as a post-doctoral fellow at the Center for Cancer Research of MIT, where she held fellowships from the Leukemia & Lymphoma Society, the AACR-Sidney Kimmel Foundation, and the American Cancer Society. She came to the CCR in 2002 and established the Genetic Modifiers of Tumorigenesis Group. In 2016, she was appointed director of the Rare Tumors Initiative. Her research focuses on mechanisms of susceptibility to nervous system tumors and preclinical models of tumors associated with neurofibromatosis type 1 (NF1).

Areas of Expertise

Nervous System Tumors
Mouse Models Of Cancer
Sex Differences In Cancer


Selected Recent Publications

The Rare Tumor Initiative in the National Cancer Institute: Harnessing expertise and existing resources to develop therapies for rare tumors

Reilly KM, Sandler AB, Widemann BC.
Oncology Central. epub - Feb. 26, 2016. [ Journal Article ]

Developing therapies for rare tumors: opportunities, challenges and progress

Bradford D, Reilly KM, Widemann BC, Sandler A, Kummar S.
Expert Opin Orphan Drugs. 4(1): 93-103, 2016. [ Journal Article ]

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA.
Neuro Oncol. [Epub ahead of print - Mar. 8]: 2016. [ Journal Article ]

Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts

Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, McMahon JB, Gustafson KR.
J Nat Prod. 78(11): 2776-81, 2015. [ Journal Article ]

Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma

Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH.
Clin Cancer Res. 21(18): 4201-11, 2015. [ Journal Article ]


Robert Tuskan, M.S.
Postdoctoral Fellow (Visiting)
Souvik Karmakar, Ph.D.
Postbaccalaureate Fellow (CRTA)
Impana Shetty