Julio C. Valencia, M.D.

Julio C. Valencia, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr Valencia's main interest is the analysis of trafficking and sorting mechanisms of melanocyte-specific proteins, both in melanocytes and in melanoma cells. His primary expertise is the analysis and applications of confocal microscopy with emphasis on the subcellular localization for organelle proteins.

Areas of Expertise

1) confocal microscopy


Selected Publications

Essential role of the molecular chaperone gp96 in regulating melanogenesis

Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z.
Pigment Cell Melanoma Res. 27: 82-9, 2014. [ Journal Article ]

Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes

Kawaguchi M, Valencia JC, Namiki T, Suzuki T, Hearing VJ.
J Invest Dermatol. 132: 2791-9, 2012. [ Journal Article ]

Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils

Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Jenkins LM, Nagashima K, Appella E, Hearing VJ.
J Biol Chem. 282: 11266-80, 2007. [ Journal Article ]

Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway

Ando H, Wen ZM, Kim HY, Valencia JC, Costin GE, Watabe H, Yasumoto K, Niki Y, Kondoh H, Ichihashi M, Hearing VJ.
Biochem J. 394: 43-50, 2006. [ Journal Article ]

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM.
Proc Natl Acad Sci U S A. 103: 9903-7, 2006. [ Journal Article ]