Joseph M. Ziegelbauer, Ph.D.

Joseph M. Ziegelbauer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Our previous research discovered functions of viral microRNAs related to inhibiting apoptosis, evading immune responses, and promoting angiogenesis. Ongoing research focuses on networks and pathways redundantly targeted by multiple viral microRNAs and circular RNAs. In collaboration with Drs. Yarchoan, Ramaswami, Lurain, and Krug in HAMB, we have been investigating human and viral gene expression patterns in normal tissue, in Kaposi sarcoma (KS), and other KSHV-infected pathological tissues. We are using a variety of expression profiling techniques and functional studies to determine the importance of these gene expression patterns. These studies will lead to the discovery of new therapeutic targets for inhibiting viral oncogenesis.

>>> Please note that our lab will not be able to accept summer students in 2024, due to lab renovations. <<<

Areas of Expertise

Kaposi's Sarcoma-Associated Herpesvirus (KSHV)
Virus-Host Interactions


Selected Key Publications

A virus-induced circular RNA maintains latent infection of Kaposi’s sarcoma herpesvirus

Tagawa T, Oh D, Dremel S, Mahesh G, Koparde VN, Duncan G, Andresson T, Ziegelbauer JM.
PNAS. 2023. [ Journal Article ]

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Ramaswami R, Tagawa T, Mahesh G, Serquina A, Koparde V, Lurain K, Dremel S, Li X, Mungale A, Beran A, Ohler ZW, Bassel L, Warner A, Mangusan R, Widell A, Ekwede I, Krug LT, Uldrick TS, Yarchoan R, Ziegelbauer JM.
Journal of Translational Medicine. 2023. [ Journal Article ]

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Sequiña AP, Lurain K, Ramaswami R, Uldrick TS, Yarchoan R, Ziegelbauer JM
Proc Natl Acad Sci U S A. 2018. [ Journal Article ]

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

Serquiña AKP, Kambach DM, Sarker O, Ziegelbauer JM
MBio. 2017. [ Journal Article ]

Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1

Ramalingam D, Happel C, Ziegelbauer JM.
PLoS Biol. 2016. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Non-coding RNAs and viruses Ph.D. or equivalent Joseph Ziegelbauer


Staff Scientist
Anna Serquina, M.D., Ph.D.
Postdoctoral Fellow
Sarah Dremel, Ph.D.
Graduate student
Ameera Mungale
Postbaccalaureate Fellow
Carmen Hernandez-Perez, B.S.
Postbaccalaureate Fellow
Julie Lee, B.S.


Learn more about CCR research advances, new discoveries and more
on our news section.


Takanobu, Tagawa, Ph.D.
Takanobu, Tagawa, Ph.D.
Postdoctoral Fellow (Visiting)