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Joseph M. Ziegelbauer, Ph.D.

Joseph M. Ziegelbauer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV and AIDS Malignancy Branch

RESEARCH SUMMARY

Dr. Ziegelbauer was the first to report using pulse labeling of proteins coupled with tandem mass spectrometry to discover human targets of herpesvirus microRNAs. His recent research has discovered functions of viral microRNAs related to inhibiting apoptosis, evading immune responses, and promoting angiogenesis. Ongoing research focuses on networks and pathways redundantly targeted by multiple viral microRNAs. Using a variety of techniques, these methods will lead to the discovery of new therapeutic targets for inhibiting viral oncogenesis.

Areas of Expertise

1) Kaposi's sarcoma-associated herpesvirus (KSHV), 2) virus-host interactions,
3) microRNAs, 4) circular RNAs, 5) expression profiling

Publications

Selected Recent Publications

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Sequiña AP, Lurain K, Ramaswami R, Uldrick TS, Yarchoan R, Ziegelbauer JM
Proc Natl Acad Sci U S A. 2018. [ Journal Article ]

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

Serquiña AKP, Kambach DM, Sarker O, Ziegelbauer JM
MBio. 2017. [ Journal Article ]

Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1

Ramalingam D, Happel C, Ziegelbauer JM.
PLoS Biol. 2016. [ Journal Article ]

KSHV microRNAs Target GADD45B to Protect Infected Cells from Cell Cycle Arrest and Apoptosis.

Liu X, Happel C, Ziegelbauer JM.
J Virol. 2016. [ Journal Article ]

Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis

Gallaher AM, Das S, Xiao Z, Andresson T, Kieffer-Kwon P, Happel C, Ziegelbauer J.
PLoS Pathog. 2013. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Anna Serquina, M.D., Ph.D.
Postdoctoral Fellow (Visiting)
Takanobu Tagawa, Ph.D.
Postdoctoral Fellow
Sarah Dremel, Ph.D.
Bioinformatician
Guruswamy Mahesh, Ph.D.
Graduate student
Ameera Mungale
Postbaccalaureate Fellow
Alex Beran, B.S.