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Jinkyu Jung, Ph.D.

Jinkyu Jung, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch

RESEARCH SUMMARY

Dr. Jung is developing novel preclinical models and therapeutic strategies that can be immediately applied for clinical trials in the brain cancer field. His research interests focus on developing newer anti-cancer drug targets and precision medicine models using computational analyses and patient-derived samples.

Areas of Expertise

1) cancer stem cells, 2) malignant gliomas, 3) targeting membrane-bound proteins, 4) anti-cancer drug evaluation, 5) tumor microenvironment, 6) tumor epigenetics

Publications

Selected Key Publications

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma.

Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM.
Cancer Res. 79(20): 5218-5232, 2019. [ Journal Article ]

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism

Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE.
Clin Cancer Res. 25(7): 2305-2313, 2019. [ Journal Article ]

Nicotinamide metabolism regulates glioblastoma stem cell maintenance

Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN.
JCI Insight. 2(10): e90019, 2017. [ Journal Article ]

Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma

Hao S, Song H, Zhang W, Seldomridge A, Jung J, Giles AJ, Hutchinson MK, Cao X, Colwell N, Lita A, Larion M, Maric D, Abu-Asab M, Quezado M, Kramp T, Camphausen K, Zhuang Z, Gilbert MR, Park DM.
Neuro Oncol. 20(6): 799-809, 2018. [ Journal Article ]

Isolation and Propagation of Glioma Stem Cells from Acutely Resected Tumors

Jung J, Gilbert MR, Park DM.
Methods Mol Biol. 1516: 361-369, 2016. [ Journal Article ]