Jay A. Berzofsky, M.D., Ph.D.

Jay A. Berzofsky, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Berzofsky pioneered characterization of B- and T-cell epitopes and their modification to make epitope-enhanced vaccines, discovered the importance of T cell avidity in viral/tumor clearance, pioneered use of defined molecular adjuvants to alter quality of immune responses, advanced mucosal HIV vaccines, discovered NKT cell regulation of tumor immunity, and blocked negative regulation by TGF-beta, IL-13, and regulatory cells to enhance tumor immunity and vaccine efficacy. He translated these strategies to clinical trials in prostate cancer, melanoma, and HER2-positive cancers. As Chief, he oversees the Vaccine Branch’s basic, translational, and clinical research in cancer and retroviral vaccines and immunotherapy.

Areas of Expertise

Cancer and HIV Vaccines
T-Cell Epitopes and Activation
Mucosal Immunity

Information for Patients

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Selected Key Publications

Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response

Sui Y, Lewis GK, Wang Y, Berckmueller K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters RC, Talton J, Klinman D, Clements J, Tomaras GD, Franchini G, Robert-Guroff M, Trinchieri G, Gallo RC, Berzofsky JA.
J Clin Invest.. 129(3): 1314-28, 2019. [ Journal Article ]

Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques

Sui Y, Dzutsev A, Venzon D, Frey B, Thovarai V, Trinchieri G, Berzofsky JA.
Mucosal Immunol. 11(4): 1219-29, 2018. [ Journal Article ]

Cancer vaccines: translation from mice to human clinical trials

Maeng H, Terabe M, Berzofsky JA.
Curr Opin Immunol. 51: 111-22, 2018. [ Journal Article ]

Expression of CD14, IL10, and Tolerogenic Signature in Dendritic Cells Inversely Correlate with Clinical and Immunologic Response to TARP Vaccination in Prostate Cancer Patients

Castiello L, Sabatino M, Ren J, Terabe M, Khuu H, Wood LV, Berzofsky JA, Stroncek DF.
Clin Cancer Res. 23(13): 3352-64, 2017. [ Journal Article ]

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Bioinformatics Analyst III (Contr.)
Matthew Angel, Ph.D.
Special Volunteer
Hana Bagheri
Postdoctoral Fellow (CRTA)
William J. Becker, Ph.D.
Research Biologist
Sophia Brown
Postdoctoral Fellow (CRTA)
Julian Burks, Ph.D.
Postdoctoral Fellow (Visiting)
Yonas B. Feyissa, Ph.D.
Tanya Hoang, B.S.
Postdoctoral Fellow (CRTA)
Savannah E. Howe, Ph.D.
Special Volunteer
Joohyun (Grace) Jin
Guest Researcher
Laurel Lagenaur, Ph.D.
Postdoctoral Fellow (Visiting)
Jianping Li, Ph.D.
Postdoctoral Fellow (Visiting)
Kumiko Nishio, M.D., Ph.D.
Staff Scientist
Purevdorj Olkhanud, M.D., Ph.D.
Research Chemist
Charles Pendleton, M.S.
Postdoctoral Fellow (CRTA)
Hanna B. Scinto, , Ph.D.
Research Fellow
Shweta Tiwary, Ph.D.
Research Biologist
Zheng Xia