Isabel Quintanilla-Leo, Ph.D.

Isabel Quintanilla-Leo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Quintanilla-Leo obtained a B.Sc in Biotechnology from the Autonomous University of Barcelona in 2010, and a M.Sc. in Biomedicine from the University of Barcelona, Spain in 2012. After that, she was a graduate student at Clinic Foundation for Biomedical Research/IDIBAPS and was awarded a Ph.D in Medical Science from the University of Barcelona, Spain in 2017. During her graduate studies, she used FISH approaches to study the role of chromosome instability and heterogeneity as a driver mechanism of colorectal cancer (CRC) formation and evolution. In 2019, she joined the Cell Biology of Genomes group as a post-doctoral fellow where she implemented in situ sequencing for spatial transcriptomic studies and for the detection of point mutations in CRC. She recently became a Staff Scientist at the CCR High-Throughput Imaging Facility (HiTIF) and she is currently working on the implementation of pooled optical phenotype screening technology.

Areas of Expertise

1) Cancer Biology 2) Chromosomal instability 3) Intratumor heterogeneity 4) Colorectal Cancer 5) Spatial Transcriptomics 6) In situ sequencing