Heather Shive photo

Heather R. Shive, D.V.M., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Shive is a research scientist and board-certified veterinary anatomic pathologist who works with the zebrafish model (Danio rerio) in comparative cancer research. Her research applies a variety of in vivo and in vitro approaches to identify and characterize genetic, phenotypic, and microenvironmental factors that promote carcinogenesis, particularly malignant peripheral nerve sheath tumor (MPNST).  Dr. Shive is also the co-director for the NIH Comparative Biomedical Scientist Training Program, a nationally recognized interdisciplinary University-NIH Graduate Partnership Program that provides an immersive residency and comparative disease research training experience for veterinary clinician scientists leading to the PhD degree.

Areas of Expertise

1) In vivo cancer modeling in zebrafish, 2) intercellular signaling, 3) genomic/genetic cancer profiling, 4) genetic engineering and xenotransplant, 5) investigative pathology, 6) comparative biomedical science graduate education


Selected Key Publications

brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis

Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD.
Proc Natl Acad Sci U S A. 107(45): 19350-5, 2010.
Full-Text Article
[ Journal Article ]

BRCA2 and TP53 collaborate in tumorigenesis in zebrafish

Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD.
PLoS One. 9(1): e87177, 2014.
Full-Text Article
[ Journal Article ]

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury

Kouprianov VA, Selmek AA, Ferguson JL, Mo X, Shive HR.
Sci Rep. 12(1): 883, 2022.
Full-Text Article
[ Journal Article ]