Haydar Bulut, Ph.D.

Haydar Bulut, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Bulut's research focuses on designing and further optimizing small-molecule inhibitors that can effectively target viral proteins to block viral replication. As a Staff Scientist at the National Cancer Institute (NCI/NIH), he has been deeply engaged in collaborative efforts with a diverse team of researchers dedicated to discovering and developing potent inhibitors that target HIV and SARS-CoV-2. Using X-ray-based structural information, Dr. Bulut has provided crucial insights into viral proteases at the atomic level, which has enhanced the optimization and development of these therapeutic interventions against HIV and COVID-19.

Areas of Expertise

Protease Inhibitors
X-Ray Crystallography
Proteins Purification


Selected Recent Publications

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.

Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H.
Nature Communications. 1076 (2023): 2023.
Full-Text Article
[ Journal Article ]

Drug development targeting SARS-CoV-2 main protease.

Bulut H,
Global Health & Medicine. 296-300.: 296-300., 2022.
Full-Text Article
[ Journal Article ]

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H.
Nature Communications. . 12: 668, 2021.
Full-Text Article
[ Journal Article ]

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.

Bulut H, Hattori SI, Aoki-Ogata H, Hayashi H, Das D, Aoki M, Davis DA, Rao KV, Nyalapatla PR, Ghosh AK, Mitsuya H.
Scientific Reports. 10: 10664, 2020.
Full-Text Article
[ Journal Article ]