National Cancer Institute - Cancer.gov

Hanqiao Feng, Ph.D.

Hanqiao Feng, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Staff Scientist
Laboratory of Biochemistry and Molecular Biology

RESEARCH SUMMARY

Our studies are focused on the structural basis of how proteins like histone chaperone, liker histones, and chromatin remodelers bind to nucleosome, modulate chromatin structure, mediate the nuclear processes like DNA repair, gene transcription, and ensure accurate segregation of chromosome. We pioneered the structural determination of protein-protein complex and protein in the complex with nucleosome by high-resolution nuclear magnetic resonance (NMR) and X-ray crystallography.

Areas of Expertise

Structural Biology
Biophysics
Structural Determination Of Protein-protein Complex
Protein-nucleosome Complex
Nuclear Magnetic Resonance (NMR)
X-ray Crystallography

Publications

Selected Publications

A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C

Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y.
Science. 340: 1110-3, 2013. [ Journal Article ]

Structural insights into the histone H1-nucleosome complex

Zhou BR, Feng H, Kato H, Dai L, Yang Y, Zhou Y, Bai Y.
Proc. Natl. Acad. Sci. U.S.A.. 110: 19390-5, 2013. [ Journal Article ]

The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer

Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y.
Mol. Cell. 53: 498-505, 2014. [ Journal Article ]

NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B

Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y.
Nat. Struct. Mol. Biol.. 15: 868-9, 2008. [ Journal Article ]

Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3

Zhou Z, Feng H, Zhou BR, Ghirlando R, Hu K, Zwolak A, Miller Jenkins LM, Xiao H, Tjandra N, Wu C, Bai Y.
Nature. 472: 234-7, 2011. [ Journal Article ]