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Francis O'Reilly

Francis J. O'Reilly, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Stadtman Investigator
Center for Structural Biology
Head, Structural Systems Biology Section

RESEARCH SUMMARY

Francis O’Reilly is a structural biologist who combines structural proteomics, electron microscopy and integrative modeling to discover and structurally characterize protein complexes directly inside cells. His laboratory develops cutting-edge crosslinking mass spectrometry tools to produce dynamic maps of protein interactomes that identify structural changes linked to diseases like cancer.

Areas of Expertise

Structural Proteomics
Crosslinking Mass Spectrometry
In Situ Structural Biology
Integrative Modeling

Publications

Selected Key Publications

Protein complexes in cells by AI-assisted structural proteomics

O‘Reilly FJ, Graziadei A, Forbrig C, Bremenkamp R, Charles K, Lenz S, Elfmann C, Fischer L, Stülke J, Rappsilber J.
bioRxiv. 2022.
Full-Text Article

Reliable identification of protein-protein interactions by crosslinking mass spectrometry

Lenz S, Sinn LR, O'Reilly FJ, Fischer L, Wegner F, Rappsilber J.
Nat Commun. 12(1): 3564, 2021. [ Journal Article ]

In-cell architecture of an actively transcribing-translating expressome

O'Reilly FJ, Xue L, Graziadei A, Sinn L, Lenz S, Tegunov D, Blötz C, Singh N, Hagen WJH, Cramer P, Stülke J, Mahamid J, Rappsilber J.
Science. 369(6503): 554-557, 2020. [ Journal Article ]

Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

O'Reilly FJ, Rappsilber J.
Nat Struct Mol Biol. 25(11): 1000-1008, 2018. [ Journal Article ]

Capturing protein communities by structural proteomics in a thermophilic eukaryote

Kastritis PL, O'Reilly FJ, Bock T, Li Y, Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull MT, Rappsilber J, Russell RB, Bork P, Beck M, Gavin AC.
Mol Syst Biol. 13(7): 936, 2017. [ Journal Article ]

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Team

Photo of Kitaik Lee of SSBS
Postdoctoral Fellow
Kitaik Lee, Ph.D.
Postdoctoral Fellow in the CCR-CSB-SSBS
Postdoctoral Fellow
Anthony Ciancone, Ph.D.
Photo of Kaylah longmore
POSTBACCALAUREATE FELLOW
Kaylah Longmore
POSTBACCALAUREATE FELLOW
Katerina Atallah-Yunes

News

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