Breadcrumb

Francis A. Flomerfelt, Ph.D.

Francis A. Flomerfelt, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology

RESEARCH SUMMARY

Francis Flomerfelt heads a transplantation immunology research facility that supports the Laboratory of Pathology through the collection of biospecimens, assistance with the preclinical development of adoptive T cell therapies, and the monitoring of engraftment, immune reconstitution, graft versus leukemia (GVL), and graft versus host disease (GVHD) following allogeneic transplantation.

Areas of Expertise

1) immune reconstitution 2) immunology 3) graft versus host disease (GVHD) 4) clinical research 

Publications

Selected Publications

Tbata modulates thymic stromal cell proliferation and thymus function

Flomerfelt, FA, El Kassar, N, Gurunathan, C, Chua, KS, League, SC, Schmitz, S, Gershon, TR, Kapoor, V, Yan, XY, Schwartz, RH and Gress, RE
J Exp Med. 207/11: 2521-2532, 2010.
Full-Text Article
[ Journal Article ]

Quantitative analysis of T cell receptor diversity in clinical samples of human peripheral blood

Memon, SA, Sportes, C, Flomerfelt, FA, Gress, RE and Hakim, FT
J Immunol Methods. 375/1-2: 84-92, 2012.
Full-Text Article
[ Journal Article ]

High levels of IL-7 cause dysregulation of thymocyte development

El-Kassar, N, Flomerfelt, FA, Choudhury, B, Hugar, LA, Chua, KS, Kapoor, V, Lucas, PJ and Gress, RE
Int Immunol. 24/10: 661-671, 2012.
Full-Text Article
[ Journal Article ]

In vivo kinetics and nonradioactive imaging of rapidly proliferating cells in graft-versus-host disease

Buxbaum, NP, Farthing, DE, Maglakelidze, N, Lizak, M, Merkle, H, Carpenter, AC, Oliver, BU, Kapoor, V, Castro, E, Swan, GA, Dos Santos, LM, Bouladoux, NJ, Bare, CV, Flomerfelt, FA, Eckhaus, MA, Telford, WG, Belkaid, Y, Bosselut, RJ and Gress, RE
JCI Insight. 2/12: 2017.
Full-Text Article
[ Journal Article ]

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

Stathopoulou, C, Gangaplara, A, Mallett, G, Flomerfelt, FA, Liniany, LP, Knight, D, Samsel, LA, Berlinguer-Palmini, R, Yim, JJ, Felizardo, TC, Eckhaus, MA, Edgington-Mitchell, L, Martinez-Fabregas, J, Zhu, J, Fowler, DH, van Kasteren, SI, Laurence, A, Bogyo, M, Watts, C, Shevach, EM and Amarnath, S
Immunity. 49/2: 247-263, 2018.
Full-Text Article
[ Journal Article ]

Team

Scientist
Ruifeng Teng, Ph.D.
Biological Scientist
Elisaveta Voynova, Ph.D.
Senior Research Assistant
Xiao-Yi Yan, Ph.D.
Research Assistant
Ping Xue, M.S.
Research Assistant
Jacob Sauber, B.S.