Donald P. Bottaro, Ph.D.

Donald P. Bottaro, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Urologic Oncology Branch


Dr. Bottaro’s research on the role of epithelial growth factors in the onset and progression of solid tumors began with the discovery of the cell surface receptors for keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF). Later work helped define the structural basis of growth factor-receptor interaction and the role of heparan sulfate proteoglycans as co-receptors. Recent efforts included translating basic knowledge of growth factor signaling to support the development of diagnostic and therapeutic agents that target HGF signaling in genitourinary and other malignancies. In July 2021, Dr. Bottaro became Special Advisor to the UOB.

Visit Experimental Cancer Therapeutics Targeting the Hepatocyte Growth Factor/Met Signaling Pathway to view a list of clinical trials for cancer therapeutics targeting the HGF/Met signaling pathway.

Areas of Expertise

Regulation Of Epithelial Cell Growth And Motility
Cellular And Molecular Oncogenesis
Growth Factor Inhibitors
Biomarker Development


Selected Key Publications

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product

Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA.
Science. 251: 802-4, 1991. [ Journal Article ]

Cancer: Out of air is not out of action

Bottaro DP, Liotta LA
Nature. 423: 593-5, 2003. [ Journal Article ]

The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells

Peruzzi B, Athauda G, Bottaro DP
Proc Natl Acad Sci U S A. 103: 14531-6, 2006. [ Journal Article ]

Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling

Cecchi F, Pajalunga D, Fowler CA, Peruzzi B, MacDonald N, Blackman DK, Stahl SJ, Byrd RA, Bottaro DP
Cancer Cell. 22: 250-62, 2012. [ Journal Article ]

Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia

Lee YH, Morrison BL, Bottaro DP.
J Biol Chem. 289: 20448-61, 2014. [ Journal Article ]