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Don Farthing, Ph.D.

Don Farthing, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

Don Farthing heads the mass spectrometry and epitope discovery facility (MSEDF) that supports preclinical and clinical researchers from the Center for Immuno-Oncology. The facility has tandem mass spectrometers (UPLC-PDA-QTof, HS-GC-QqQ) that are utilized to support translational research (e.g., development of adoptive T cell therapies, graft- versus-host disease, deuterium imaging of rapidly proliferating cells).

Areas of Expertise

1) chromatography-mass spectrometry 2) analytical chemistry 3) pharmacokinetic/pharmacodynamic (PK/PD) analysis 4) toxicology 5) clinical pharmacology

Publications

Glycolytic metabolism of pathogenic T cells enables early detection of GVHD by 13C-MRI

Assmann, JC, Farthing, DE, Saito, K, Maglakelidze, N, Oliver, B, Warrick, KA, Sourbier, C, Ricketts, CJ, Meyer, TJ, Pavletic, SZ, Linehan, WM, Krishna, MC, Gress, RE and Buxbaum, NP
Blood. 137/1: 126-137, 2021.
Full-Text Article
[ Journal Article ]

Comparing DNA enrichment of proliferating cells following administration of different stable isotopes of heavy water

Farthing, DE, Buxbaum, NP, Lucas, PJ, Maglakelidze, N, Oliver, B, Wang, J, Hu, K, Castro, E, Bare, CV and Gress, RE
Sci Rep. 7/1: 4043, 2017.
Full-Text Article
[ Journal Article ]

In vivo kinetics and nonradioactive imaging of rapidly proliferating cells in graft-versus-host disease

Buxbaum, NP, Farthing, DE, Maglakelidze, N, Lizak, M, Merkle, H, Carpenter, AC, Oliver, BU, Kapoor, V, Castro, E, Swan, GA, Dos Santos, LM, Bouladoux, NJ, Bare, CV, Flomerfelt, FA, Eckhaus, MA, Telford, WG, Belkaid, Y, Bosselut, RJ and Gress, RE
JCI Insight. 2/12: 2017.
Full-Text Article

Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo

Amarnath, S, Foley, JE, Farthing, DE, Gress, RE, Laurence, A, Eckhaus, MA, Metais, JY, Rose, JJ, Hakim, FT, Felizardo, TC, Cheng, AV, Robey, PG, Stroncek, DE, Sabatino, M, Battiwalla, M, Ito, S, Fowler, DH and Barrett, AJ
Stem Cells. 33/4: 1200-1212, 2015.
Full-Text Article
[ Journal Article ]

Sensitive GC-MS/MS method to measure deuterium labeled deoxyadenosine in DNA from limited mouse cell populations

Farthing, DE, Buxbaum, NP, Bare, CV, Treadwell, SM, Kapoor, V, Williams, KM and Gress, RE
Anal Chem. 85/9: 4613-4620, 2013.
Full-Text Article
[ Journal Article ]