Di  Xia, Ph.D.

Di Xia, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cell Biology


Dr. Xia devotes his research to the structure and function relationship of membrane proteins at atomic resolution. He determined the crystal structures of Complex III or cytochrome bc1 complex of respiratory and photosynthetic apparatus and elucidated mechanisms of its function and antibiotic resistance. These works form the foundation that guides rational drug design against Complex III of pathogenic organisms.

Recently, Dr. Xia has focused his attention to the structural mechanism of multidrug resistance mediated by membrane transporters. Structural revelation of these transporters promise a detailed understanding of how diverse drugs are pumped and how resistance might be reversed.

Areas of Expertise

Membrane Protein
Drug Resistance
Electron Transport


Selected Recent Publications

Structures of AAA Protein Translocase Bcs1 Suggest Translocation Mechanism of a Folded Protein

Tang WK, Borgnia MJ, Hsu AL, Esser L, Fox T, de Val N, Xia D.
Nat Struct Mol Biol. 27(2): 202-9, 2020. [ Journal Article ]

A Spiral Path to Unfolding

Ye Y, Xia D.
Nat Struct Mol Biol. 26(9): 763-65, 2019. [ Journal Article ]

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP.
J Invest Dermatol. 139(9): 1985-92, 2019. [ Journal Article ]

Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III

Esser L, Zhou F, Zhou Y, Xiao Y, Tang WK, Yu CA, Qin Z, Xia D.
J Biol Chem. 291(48): 25019-31, 2016. [ Journal Article ]

In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed

Xia D, Ye Y.
Cancer Cell. 28(5): 550-2, 2015. [ Journal Article ]

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Staff Scientist
Lothar Esser, Ph.D.
Predoctoral Visiting Fellow (Graduate Student)
Jingyu Zhan
Postdoctoral Fellow (Visiting Fellow)
Raghupathi Kummari, Ph.D.
Post-baccalaureate Fellow
Abraham Morton
Staff Scientist
Rick Huang, Ph.D.
Post-Baccalaureate Fellow
Zabrina Lang
Post-baccalaureate Fellow
Carolyn Maslanka


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