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Debananda  Das, Ph.D.

Debananda Das, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Magnuson Clinical Center, Room 5A11
  • Bethesda, MD 20892-1868
  • 240-858-3254
  • dasd@mail.nih.gov

RESEARCH SUMMARY

Dr. Das's current research interests are as follows: 1) Discovery and optimization of small molecule inhibitors against SARS-CoV-2.  2) Determining the (structural) mechanism of resistance of HIV against protease and reverse transcriptase inhibitors. 3) Structural interactions of nucleoside reverse transcriptase inhibitors against Hepatitis-B virus (HBV) and 4) virtual screening to identify new classes of inhibitors against HIV.

Areas of Expertise

Anti-HIV Inhibitors
Anti-SARS-CoV-2 Inhibitors
Structure-based Discovery And Design Of Small Molecule Inhibitors
Virtual Screening For Small Molecule Lead Identification
Structure To Function Relationships
Computational Structural Biology And Computational Chemistry

Publications

Selected Key Publications

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh & Hiroaki Mitsuya
Nature Communications. 12: 668, 2021.
Full-Text Article
[ Journal Article ]

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

Shin-ichiro Hattori, Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, David A. Davis, Yuki Takamatsu, Kouki Matsuda, Nobutoki Takamune, Naoki Kishimoto, Tadashi Okamura, Shogo Misumi, Robert Yarchoan, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya
mBio. 11: e01833-20, 2020.
Full-Text Article
[ Journal Article ]

Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Nobuyo Higashi-Kuwata, Sanae Hayashi, Hiroki Kumamoto, Hiromi Ogata-Aoki, Debananda Das, David Venzon, Shin-ichiro Hattori, Haydar Bulut, Mai Hashimoto, Masaki Otagiri, Nobutoki Takamune, Naoki Kishimoto, David A. Davis, Shogo Misumi, Masakazu Kakuni, Yasuhito Tanaka, Hiroaki Mitsuya
Journal of Hepatology. 74: 1075-1086, 2021.
Full-Text Article
[ Journal Article ]

Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s

Hirotomo Nakata, Kenji Maeda, Debananda Das, Simon B. Chang, Kouki Matsuda, Kalapala Venkateswara Rao, Shigeyoshi Harada, Kazuhisa Yoshimura, Arun K. Ghosh and Hiroaki Mitsuya
Scientific Reports. 9/1: 4828, 2019.
Full-Text Article
[ Journal Article ]

Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors

Debananda Das, Kenji Maeda, Yasuhiro Hayashi, Navnath Gavande, Darshan V. Desai, Simon B. Chang, Arun K. Ghosh, and Hiroaki Mitsuya
Antimicrobial Agents and Chemotherapy. 59/4: 1895-1904, 2015.
Full-Text Article
[ Journal Article ]