Debananda Das, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10 - Magnuson Clinical Center, Room 5A11
- Bethesda, MD 20892-1868
- 240-858-3254
- dasd@mail.nih.gov
RESEARCH SUMMARY
Dr. Das's current research interests are as follows: 1) Discovery and optimization of small molecule therapies against human diseases. 2) Determining the (structural) mechanism of drug resistance. and 3) virtual screening to identify new classes of therapies against human diseases.
Areas of Expertise
Debananda Das, Ph.D.
Research
Dr. Das' current research interests are as follows:
1. Mechanism of drug resistance. We use a combination of enzyme kinetics, x-ray crystallography and molecular dynamics simulations to unambiguously characterize the mechanism of binding of small molecule inhibitors and to determine the structural changes that contribute to drug resistance. The research helps in designing newer generation of inhibitors with improved potency and resistance profile.
Publications
- Bibliography Link
- View Dr. Das' PubMed Summary
Biography
Debananda Das, Ph.D.
Dr. Das has a M.S. in chemistry from the Indian Institute of Technology, Kanpur, a M.Tech. in chemical analysis from the Indian Institute of Technology, Delhi, and a Ph.D. in chemistry from the University of New Orleans (Advisor: Prof. Scott Whittenburg). His postdoctoral research was on QM/MM methods and applications in the group of Dr. Bernard Brooks at NHLBI/NIH. He worked for Tripos, Inc. before joining the HIV & AIDS Malignancy Branch (HAMB) at NCI in 2005. At HAMB, he works in a multi-disciplinary environment focusing on the design, synthesis, and development of the next-generation of therapeutic agents against HIV, and other diseases.