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Debananda  Das, Ph.D.

Debananda Das, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Magnuson Clinical Center, Room 5A11
  • Bethesda, MD 20892-1868
  • 240-858-3254
  • dasd@mail.nih.gov

RESEARCH SUMMARY

Dr. Das's current research interests are as follows: 1) Discovery and optimization of small molecule therapies against human diseases.  2) Determining the (structural) mechanism of drug resistance. and 3) virtual screening to identify new classes of therapies against human diseases.

Areas of Expertise

Discovery of small molecule inhibitors
Structure based drug design against human diseases
Virtual Screening For Small Molecule Lead Identification
Structure To Function Relationships
Computational Structural Biology And Computational Chemistry

Publications

Selected Key Publications

HIV-1 protease inhibitors and mechanisms of HIV-1's resistance

Debananda Das
Global Health and Medicine. 6: 357-362, 2024.
Full-Text Article
[ Journal Article ]

Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Nobuyo Higashi-Kuwata, Sanae Hayashi, Hiroki Kumamoto, Hiromi Ogata-Aoki, Debananda Das, David Venzon, Shin-ichiro Hattori, Haydar Bulut, Mai Hashimoto, Masaki Otagiri, Nobutoki Takamune, Naoki Kishimoto, David A. Davis, Shogo Misumi, Masakazu Kakuni, Yasuhito Tanaka, Hiroaki Mitsuya
Journal of Hepatology. 74: 1075-1086, 2021.
Full-Text Article
[ Journal Article ]

Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s

Hirotomo Nakata, Kenji Maeda, Debananda Das, Simon B. Chang, Kouki Matsuda, Kalapala Venkateswara Rao, Shigeyoshi Harada, Kazuhisa Yoshimura, Arun K. Ghosh and Hiroaki Mitsuya
Scientific Reports. 9/1: 4828, 2019.
Full-Text Article
[ Journal Article ]

Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors

Debananda Das, Kenji Maeda, Yasuhiro Hayashi, Navnath Gavande, Darshan V. Desai, Simon B. Chang, Arun K. Ghosh, and Hiroaki Mitsuya
Antimicrobial Agents and Chemotherapy. 59/4: 1895-1904, 2015.
Full-Text Article
[ Journal Article ]