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David Takeda, M.D., Ph.D.

David Takeda, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genitourinary Cancer Pathogenesis

RESEARCH SUMMARY

Dr. Takeda’s research is focused on understanding the role of epigenetic reprogramming in disease progression by combining genomic and epigenomic profiling of patient samples with functional studies in model systems. Current areas of investigation include identifying noncoding drivers of castration-resistance in prostate cancer, interrogating regulatory elements using unbiased proteomic and genetic approaches, and therapeutic targeting of oncogenic transcriptional programs in genitourinary cancers.

Areas of Expertise

1) epigenetics, 2) functional genomics, 3) chromatin, 4) prostate cancer, 5) androgen receptor, 6) treatment resistance

Publications

Selected Recent Publications

A somatically acquired enhancer of the androgen receptor is a noncoding driver in advanced prostate cancer

Takeda DY*, Spisak S*, Seo JH, Bell C, O’Conner E, Korthauer K, Ribli D, Csabai I, Solymosi N, Szallasi Z, Stillman DR, Cejas P, Qiu X, Long H, Tisza V, Nuzzo PV, Rohanizadegan M, Pomerantz MM, Hahn WC, Freedman ML. (*co-first author)
Cell. 174(2): 422-432, 2018. [ Journal Article ]

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

Pomerantz MM, Qiu X, Zhu Y, Takeda DY, Pan W, Baca SC, Gusev A, Korthauer KD, Severson TM, Ha G, Viswanathan SR, Seo JH, Nguyen HM, Zhang B, Pasaniuc B, Giambartolomei C, Alaiwi SA, Bell CA, O'Connor EP, Chabot MS, Stillman DR, Lis R, Font-Tello A, Li L, Cejas P, Bergman AM, Sanders J, van der Poel HG, Gayther SA, Lawrenson K, Fonseca MA, Reddy J, Corona RI, Martovetsky G, Egan B, Choueiri T, Ellis L, Garraway IP, Lee GM, Corey E, Long HW, Zwart W, Freedman ML
Nature Genetics. 52(8): 790-799, 2020. [ Journal Article ]

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Baca SC, Takeda DY, Seo JH, Hwang J, Ku SY, Arafeh R, Arnoff T, Agarwal S, Bell C, O'Connor E, Qiu X, Alaiwi SA, Corona RI, Fonseca MAS, Giambartolomei C, Cejas P, Lim K, He M, Sheahan A, Nassar A, Berchuck JE, Brown L, Nguyen HM, Coleman IM, Kaipainen A, De Sarkar N, Nelson PS, Morrissey C, Korthauer K, Pomerantz MM, Ellis L, Pasaniuc B, Lawrenson K, Kelly K, Zoubeidi A, Hahn WC, Beltran H, Long HW, Brown M, Corey E, Freedman ML.
Nature Communications. Mar 30;12(1): 1979, 2021. [ Journal Article ]

Mutational processes shape the landscape of TP53 mutations in human cancer

Giacomelli AO, Yang X, Linter RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CW, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC.
Nature Genetics. 50(10): 1381-1387, 2018. [ Journal Article ]

The androgen receptor is extensively reprogrammed in human prostate tumorigenesis

Pomerantz MM*, Li F*, Takeda DY*, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, Loda M, Long HW, Freedman ML. (*co-first author)
Nature Genetics. 47(11): 1346-1351, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Epigenetics, functional genomics, cancer Ph.D. or equivalent David Takeda david.takeda@nih.gov

Team

Postdoctoral Fellow (CRTA)
Aleksandra Adamovich , Ph.D.
Postdoctoral Fellow (Visiting)
Shin-Ai Lee, Ph.D.
Postbaccalaureate Fellow (CRTA)
Clara Seo
Postbaccalaureate Fellow (CRTA)
Matt Kipp
Postbaccalaureate Fellow (CRTA)
Rachel Xiang