David A. Davis, Ph.D.

David A. Davis, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Davis’ current projects involve the development of novel therapies for the treatment of AIDS Malignancies. He currently studies oncoviruses and the treatment of their related diseases with immunomodulatory drugs . Previous work involved studies on regulation of HIV-1 protease and protease inhibitors. As a staff scientist in the Yarchoan lab, Dr. Davis mentors postdoctoral fellows as well as junior scientists in the area of viral oncology. The laboratory has a translational research focus that allows for cross-talk between the clinic and lab aiding in the development of new antiviral and anticancer therapies.

Areas of Expertise

Virus Oncology
Protein Chemistry
Oxidative Stress


Selected Publications

Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro

Davis DA, Newcomb FM, Starke DW, Ott DE, Mieyal JJ, Yarchoan R.
J. Biol. Chem.. 272: 25935-40, 1997. [ Journal Article ]

Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus

Davis DA, Rinderknecht AS, Zoeteweij JP, Aoki Y, Read-Connole EL, Tosato G, Blauvelt A, Yarchoan R.
Blood. 97: 3244-50, 2001. [ Journal Article ]

Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi"s sarcoma-associated herpesvirus infected cells

Davis DA, Singer KE, Reynolds IP, Haque M, Yarchoan R.
Cancer Res.. 67: 7003-10, 2007. [ Journal Article ]

Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide

Daniels SI, Soule EE, Davidoff KS, Bernbaum JG, Hu D, Maeda K, Stahl SJ, Naiman NE, Waheed AA, Freed EO, Wingfield P, Yarchoan R, Davis DA.
FASEB J.. 28: 106-16, 2014. [ Journal Article ]

Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation

Davis DA, Brown CA, Newcomb FM, Boja ES, Fales HM, Kaufman J, Stahl SJ, Wingfield P, Yarchoan R.
J Virol. 77: 3319-25, 2003. [ Journal Article ]