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Christian T. Mayer, Ph.D.

Christian T. Mayer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch

RESEARCH SUMMARY

Dr. Mayer’s laboratory is interested in mechanisms of immune regulation, particularly the role of cell death in self-tolerance and adaptive immunity. His current research program focuses on unraveling the regulatory networks controlling cell death and determining their roles in immune cell development, differentiation and function in part by using a novel apoptosis reporter mouse he developed. These studies serve to increase our fundamental understanding of immune responses and of how defects in immune regulation might contribute to diseases. The long-term goals are to identify new therapeutic strategies to (1) inhibit unwanted immune responses, (2) enhance immune responses against tumors and pathogens.

Areas of Expertise

1) B lymphocyte differentiation and function, 2) antibodies, 3) self-tolerance and autoimmunity, 4) cell death, 5) immunology, 6) animal models

Publications

Selected Recent Publications

An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells.

Mayer CT*, Nieke JP, Gazumyan A, Cipolla M, Wang Q, Oliveira TY, Ramos V, Monette S, Li QZ, Gershwin ME, Kashkar H, Nussenzweig MC*. (* Corresponding authors)
Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2015372117: 2020. [ Journal Article ]

The microanatomic segregation of selection by apoptosis in the germinal center

Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC.
Science. 358(6360): eaao2602, 2017. [ Journal Article ]

T cell help controls the speed of the cell cycle in germinal center B cells.

Gitlin AD, Mayer CT, Oliveira TY, Shulman Z, Jones MJ, Koren A, Nussenzweig MC.
Science. 349(6248): 643-6, 2015. [ Journal Article ]

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stüve P, Puttur F, Merad M, Sparwasser T.
Blood. 124(20): 3081-91, 2014. [ Journal Article ]

Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma

Klages K*, Mayer CT*, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T. (*equal contribution)
Cancer Res. 70(20): 7788-99, 2010. [ Journal Article ]

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