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Headshot of Brynn Duncan

Brynn B. Duncan, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Assistant Research Physician
Pediatric Oncology Branch

RESEARCH SUMMARY

Dr. Duncan is a pediatric oncologist and physician scientist in the Hematologic Malignancies Section of the Pediatric Oncology Branch. Her clinical interests include implementation of novel chimeric antigen receptor T cell therapies for treatment of leukemia and lymphoma in children, adolescents, and young adults. Her research focuses on using translational approaches to understand CAR T cell trafficking in nonhuman primates.

Areas of Expertise

Pediatric Oncology
Chimeric Antigen Receptor (CAR) T-Cell Therapy
Adoptive Immune Cell Therapy
Leukemia and Lymphoma
Translational CAR T-Cell Engineering and Trafficking

Publications

Selected Key Publications

Applying a clinical lens to animal models of CAR-T cell therapies

Duncan BB, Dunbar CE, Ishii K.
Molecular Therapy Methods & Clinical Development. 2022.
Full-Text Article
[ Journal Article ]

Treatment of refractory/relapsed Diamond-Blackfan anaemia with eltrombopag

Duncan BB, Lotter JL, Superata J, Barranta ME, Machado T, Darden I, Venugopal S, Wu CO, Abkowitz JL, Dunbar CE, Young DJ.
British Journal of Haematology. 2024.
Full-Text Article
[ Journal Article ]

Murine pre-B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor.

Qin H, Ishii K, Nguyen S, Su PP, Burk CR, Kim BH, Duncan BB, Tarun S, Shah NN, Kohler ME, Fry TJ.
Blood. 2018.
Full-Text Article
[ Journal Article ]

CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease.

Pehlivan KC, Duncan BB, Lee DW.
Current Hematologic Malignancy Reports. 2018.
Full-Text Article
[ Journal Article ]

A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy.

Duncan BB, Highfill SL, Qin H, Bouchkouj N, Larabee S, Zhao P, Woznica I, Liu Y, Li Y, Wu W, Lai JH, Jones B, Mackall CL, Bachovchin WW, Fry TJ.
Journal of Immunotherapy.. 2013.
Full-Text Article
[ Journal Article ]