New clinical trial evaluates chemotherapy delivery for stomach cancer

Peritoneal carcinomatosis

Peritoneal carcinomatosis in a 30-year-old woman with malignant melanoma.
Photo courtesy of Research Gate

Patients with advanced stomach cancer that has spread to the lining of the abdominal cavity may be eligible to participate in a new clinical trial at the NIH Clinical Center.

Jeremy L. Davis, M.D., Associate Research Physician in the Surgical Oncology Program, is leading a study to test a way to treat advanced stomach cancer that has spread outside the stomach to the peritoneum. The peritoneum is a thin layer of tissue that lines the abdomen and encases most of the abdominal organs. Peritoneal carcinomatosis is a rare condition in which stomach cancer spreads, causing tumors to grow in multiple places in the abdominal cavity. In this study, patients will receive a combination chemotherapy with one drug taken orally and the other by injection in the arm and directly to the peritoneum. In a surgical procedure called laparoscopy, a port with a catheter attached will be put into the abdominal cavity. The port will remain in place throughout the study. After the study treatment ends, patients will be followed to check the progression of their tumors. Investigators aim to see if this combination therapy and delivery will improve outcomes for patients with gastric cancer that has spread to the peritoneum.

Clinicaltrials.gov identifier: NCT04034251
NCI Protocol ID: NCI-19-C-0129
Official Title: A Phase II Study of Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis

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Summary Posted: Thu, 06/18/2020