Clinical trial tests a PARP inhibitor in urothelial cancer with DNA-repair defects

Anatomy of female urinary system

Anatomy of the female urinary system
Photo credit: NCI Visuals Online

Patients with metastatic or advanced urothelial cancer with DNA-repair defects may be eligible to participate in a new clinical trial at the NIH Clinical Center.

Urothelial carcinoma (UC), or bladder cancer, is cancer of the cells that line the inside of all the organs of the urinary tract (bladder, urethra, ureters and parts of the kidneys). It is the most common cancer of the urinary tract, and it can spread to other parts of the body. Treatment options are limited for patients with metastatic UC. Like every cell in the body, UC cells contain DNA that controls how the cells copy themselves. When this DNA is damaged, the body has ways of repairing it so that the cells can continue to multiply. An enzyme called PARP can repair breaks in DNA and thus keep cells multiplying normally. Andrea B. Apolo, M.D., of the Genitourinary Malignancies Branch, is leading a study of olaparib, a drug designed to target cancers that have defective DNA-repair mechanisms in their cells by inhibiting the action of PARP. Investigators want to test how UC responds to PARP inhibition with olaparib.  

Clinicaltrials.gov identifier: NCT03375307
NCI Protocol ID: NCI-19-C-0023
Official Title: A Phase II Study of Olaparib (AZD2281) in Patients With Metastatic/Advanced Urothelial Carcinoma With DNA-Repair Defects

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Summary Posted: Thu, 04/18/2019