Clinical trial studies combination therapy for B-cell lymphoma that has spread to the central nervous system

Large B-cell lymphoma

Large B-cell lymphoma
Photo credit: Wikimedia Commons

Patients with untreated or non-responding B-cell lymphoma that has spread to the central nervous system may be eligible to participate in a new clinical trial at the NIH Clinical Center.

Mark Roschewski, M.D., Senior Clinician in the Lymphoid Malignancies Branch, is leading a study of a new therapy to treat aggressive B-cell lymphoma that has spread to the brain and spinal cord (central nervous system or CNS). Lymphomas are “blood cancers” in the lymph nodes; B-cell lymphomas affect B  cells, a type of white blood cell that fights infections. Secondary central nervous system lymphoma (sCNSL) is a rare cancer that starts in B cells and spreads to the CNS. There is no standard treatment for sCNSL leading researchers to test a new treatment regimen that combines six drugs that work in different ways to fight cancer: temozolomide, etoposide, Doxil, dexamethasone, ibrutinib and rituximab, together known as TEDDI-R. In a previous study, TEDDI-R improved outcomes for some patients with lymphoma that originated in the CNS. The goal of this study is to see if TEDDI-R is safe and can improve outcomes for patients with B-cell lymphoma that has spread to the CNS.     

Clinicaltrials.gov identifier: NCT03964090
NCI Protocol ID: NCI-19-C-0103
Official Title: A Study of Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

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Summary Posted: Tue, 10/15/2019