Ross Lake is the head of the Laboratory of Genitourinary Cancer Pathogenesis (LCGP) Microscopy Core Facility, which provides state-of-the-art equipment, materials, and expertise to researchers in the LGCP. In addition, the Core is open to scientists at the National Cancer Institute. The Core instruments include a Carl Zeiss LSM 780 laser scanning confocal microscope, a Zeiss AxioScan Z1 fluorescent slide scanner, an Olympus VivaView Incubator Microscope, and a pair of Carl Zeiss Axio Observer epifluorescent microscopes. The Core provides access to cutting-edge technology and training on the Core's instruments as well as assistance with experimental design.
1) microscopy, 2) immunofluorescence, 3) immunohistochemistry
In addition to managing the LGCP Microscopy Core, Ross also conducts research in collaboration with Dr. Kathy Kelly on the role of CD97, an adhesion class GPCR, in tumor progression and metastasis.
Selected Recent Publications
Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration.Cell Reports. 23(3): 808-822, 2018. [ Journal Article ]
Mechanical properties of the tumor stromal microenvironment probed in vitro and ex vivo by in situ-calibrated optical trap-based active microrheology.Cell Mol Bioeng. 9(3): 398-417, 2016. [ Journal Article ]
- Oncotarget. 7(13): 16517-28, 2016. [ Journal Article ]
- Cell Reports. 13: 2147–2158, 2015. [ Journal Article ]
- Oncogene. 32: 2726-2738, 2013. [ Journal Article ]
Ross Lake has been a SRA in the LGCP Microscopy Core Facility in the Center for Cancer Research of the NCI for over 14 years. He has extensive experience in cell and molecular biology, immunohistochemistry, immunofluorescence, as well as in microscopy. Ross has managed the LGCP Microscopy Core Facility since December 2014.