Highlighted Publications

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry.
Paul D, Bolhuis DL, Yan H, Das S, Xu X, Abbate CC, Jenkins LMM, Emanuele MJ, Andresson T, Huang J, Albeck JG, Brown NG, Cappell SD. 2025.
Nature. 2025 July 30. doi: 10.1038/s41586-025-09328-w

Schematic of the events during cell cycle entry, glycolysis and APC/C activity — Schematic of the events during cell cycle entry, glycolysis and APC/C activity.

Proteomic analysis of tumor cell nuclear expulsion reveals significant cell adhesion and RNA binding programs in extracellular chromatin.
Gray JM, Park WY, Holewinski RJ, Andresson T, Carmona-Rivera C, Kaplan MJ, Yang L.
Scientific Reports. 2025 Aug 01;15:28054. doi: 10.1038/s41598-025-11807-z

Immunofluorescence staining of cell adhesion proteins and TuNEPs — Immunofluorescence staining of the cell adhesion protein BSG (red) and TuNEPs (green) in MDA-MB-231-LM3 cells.

Pericytes require physiological oxygen tension to maintain phenotypic fidelity.
McErlain T, McCulla EC, Glass MJ, Ziemer LE, Branco CM, Murgai M.
Scientific Reports. 2024 Nov 28;14:29581. doi: 10.1038/s41598-024-80682-x

Immunofluorescence characterization of primary pericyte cultures from mouse. — Immunofluorescent staining for pericyte markers NG2, PDGFRb, ACTA2, and MYH11 in primary pericyte cultures derived from mouse lung.

Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression.
Zahraeifard S, Xiao Z, So JY, Ahad A, Montoya S, Park WY, Sornapudi T, Andohkow T, Read A, Kedei N, Koparde V, Yang H, Lee M, Wong N, Cam M, Wang K, Ruppin E, Luo J, Hollander C, Yang L.
Nature Communications. 2024 July;15:5873. doi: 10.1038/s41467-024-50262-8

Schematic hypothesis showing how NF1, TSC1, or TβRII deficiency leads to altered inflammatory and immune suppressive microenvironment — Schematic hypothesis showing how NF1, TSC1, or TβRII deficiency leads to altered inflammatory and immune suppressive microenvironment.

Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells.
Zhang H, Read A, Cataisson C, Yang HH, Lee W-C, Turk BE, Yuspa SH, Luo J.
Science Signaling. 2024 May;17:eadd5073. doi: 10.1126/scisignal.add5073

A model of the molecular mechanism by which PPP6c deletion confers resistance to MAPK pathway inhibition in KRAS- and BRAF-mutant cancer cells.

Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal.
Cornwell JA, Crncec A, Afifi MM, Tang K, Amin R, Cappell SD.
Nature. 2023 Jul;619(7969):363-370. doi: 10.1038/s41586-023-06274-3

Schematic of the cell cycle feed-forward loop — A feed-forward loop underlies CDK2 reversibility.