Fatima Karzai, M.D.

Fatima Karzai, M.D.
Associate Research Physician
Clinic Chief and Inpatient Director

Dr. Karzai's clinical research is focused on immunotherapeutic therapies and DNA damage repair pathways. Her interests lie in the field of hormonally driven cancers and clinical trial development, particularly in advanced prostate cancer. Dr. Karzai's work emphasizes novel combination therapies involving immunotherapeutic agents, small molecules, and cytotoxic therapies. Her mission is to provide patients with novel treatment strategies that harness the power of the immune system.

Areas of Expertise

1) immunotherapy, 2) hormonally driven cancers, 3) immune checkpoint inhibitors, 4) PARP inhibitors, 5) DNA damage repair

Contact Info

Fatima Karzai, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 13N240
Bethesda, MD 20892
Ph: 301-480-8870
Fax: 301-480-8867

As Clinic Chief and Inpatient Director for the Genitourinary Malignancies Branch, Dr. Karzai is passionate about patient care and clinical research. Dr. Karzai's research is focused on novel combination therapies in prostate cancer, particularly with immunotherapeutic agents such as immune checkpoint blocking antibodies and agents targeting defects in DNA damage repair pathways. The Genitourinary Malignancies Branch enrolls patients onto clinical trials in all stages of prostate cancer.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Genetics and Genomics, Health Disparities, Immunology

Selected Key Publications

  1. Karzai FH, Apolo AB, Cao L, Madan RA, Adelberg DE, Parnes H, McLeod DG, Harold N, Peer C, Yu Y, Tomita Y, Lee MJ, Lee S, Trepel JB, Gulley JL, Figg WD, Dahut WL.
    BJU Int. 116(4): 546-555, 2015. [ Journal Article ]
  2. Apolo AB, Karzai FH, Trepel JB, Alarcon S, Lee S, Lee MJ, Tomita Y, Cao L, Yu Y, Merino MJ, Madan RA, Parnes HL, Steinberg SM, Rodriguez BW, Seon BK, Gulley JL, Arlen PM, Dawson NA, Figg WD, Dahut WL.
    Clin Genitourin Cancer. 15(1): 77-85, 2017. [ Journal Article ]
  3. Karzai FH, Madan RA, Dahut WL.
    Future Oncol. 12(16): 1947-1955, 2016. [ Journal Article ]

Dr. Karzai received her M.D. from The George Washington University School of Medicine and Health Sciences in Washington, DC where she also completed her Internal Medicine residency. She completed her fellowship in Medical Oncology and Hematology at the National Cancer Institute (NCI) and the National Heart, Lung, and Blood Institute (NHLBI) at NIH. Upon completion of her fellowship, she continued her work with the Genitourinary Malignancies Branch at the NCI as a Staff Clinician. Dr. Karzai is board certified in medical oncology and internal medicine.