David A. Davis, Ph.D.
David A. Davis, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Building 10, Room 10S255
Bethesda, MD 20876
301-402-3630

Dr. Davis’ current projects involve the development of novel therapies for the treatment of AIDS Malignancies. He also studies the role of oxidative stress in the human herpesvirus 8 (HHV-8) life cycle. Previous work involved studies on regulation of HIV-1 protease.

As a staff scientist in the Yarchoan lab, Dr. Davis mentors postdoctoral fellows as well as junior scientists in the area of viral oncology. The laboratory has a translational research focus that allows for cross-talk between the clinic and lab aiding in the development of new antiviral and anticancer therapies.

Areas of Expertise
virus oncology, protein chemistry, oxidative stress, proteases, hypoxia

I have been a Staff Scientist in the National Cancer Institute, NIH in the HIV and AIDS Malignancy Branch (HAMB) since 1996. I currently oversee the laboratory projects carried out by PostBacs and the post docs in the lab as well as carry out my own research. Our lab has been extensively studying the role of hypoxia and hypoxia response elements in human herpesvirus 8 (also known as KSHV) activation as it relates to malignancies associated with AIDS. We also study the role of the HIV-1 protease in the HIV-1 viral life cycle and work on protease inhibitor/drug development. I specialize in protein biochemistry, enzymology, oxidative stress and RP-HPLC mass spectrometry. Current projects involve the development of dimerization inhibitors of the HIV-1 protease and the role of oxidative stress in HHV-8 life cycle. Like many scientists I am also an amateur musician, singer, songwriter.

Selected Publications
  1. Daniels SI, Soule EE, Davidoff KS, Bernbaum JG, Hu D, Maeda K, Stahl SJ, Naiman NE, Waheed AA, Freed EO, Wingfield P, Yarchoan R, Davis DA.
    FASEB J.. 28: 106-16, 2014. [ Journal Article ]
  2. Davis DA, Brown CA, Newcomb FM, Boja ES, Fales HM, Kaufman J, Stahl SJ, Wingfield P, Yarchoan R.
    J Virol. 77: 3319-25, 2003. [ Journal Article ]
  3. Davis DA, Newcomb FM, Starke DW, Ott DE, Mieyal JJ, Yarchoan R.
    J. Biol. Chem.. 272: 25935-40, 1997. [ Journal Article ]
  4. Davis DA, Rinderknecht AS, Zoeteweij JP, Aoki Y, Read-Connole EL, Tosato G, Blauvelt A, Yarchoan R.
    Blood. 97: 3244-50, 2001. [ Journal Article ]
  5. Davis DA, Singer KE, Reynolds IP, Haque M, Yarchoan R.
    Cancer Res.. 67: 7003-10, 2007. [ Journal Article ]

Masters of Science, Biochemistry-University of Vermont 1987 PhD, Biochemistry-Purdue University 1992 PostDoc 1992-1995, NHLBI, NIH Staff Scientist-1996-present

Summary

Dr. Davis’ current projects involve the development of novel therapies for the treatment of AIDS Malignancies. He also studies the role of oxidative stress in the human herpesvirus 8 (HHV-8) life cycle. Previous work involved studies on regulation of HIV-1 protease.

As a staff scientist in the Yarchoan lab, Dr. Davis mentors postdoctoral fellows as well as junior scientists in the area of viral oncology. The laboratory has a translational research focus that allows for cross-talk between the clinic and lab aiding in the development of new antiviral and anticancer therapies.

Areas of Expertise
virus oncology, protein chemistry, oxidative stress, proteases, hypoxia

Research

I have been a Staff Scientist in the National Cancer Institute, NIH in the HIV and AIDS Malignancy Branch (HAMB) since 1996. I currently oversee the laboratory projects carried out by PostBacs and the post docs in the lab as well as carry out my own research. Our lab has been extensively studying the role of hypoxia and hypoxia response elements in human herpesvirus 8 (also known as KSHV) activation as it relates to malignancies associated with AIDS. We also study the role of the HIV-1 protease in the HIV-1 viral life cycle and work on protease inhibitor/drug development. I specialize in protein biochemistry, enzymology, oxidative stress and RP-HPLC mass spectrometry. Current projects involve the development of dimerization inhibitors of the HIV-1 protease and the role of oxidative stress in HHV-8 life cycle. Like many scientists I am also an amateur musician, singer, songwriter.

Publications

Selected Publications
  1. Daniels SI, Soule EE, Davidoff KS, Bernbaum JG, Hu D, Maeda K, Stahl SJ, Naiman NE, Waheed AA, Freed EO, Wingfield P, Yarchoan R, Davis DA.
    FASEB J.. 28: 106-16, 2014. [ Journal Article ]
  2. Davis DA, Brown CA, Newcomb FM, Boja ES, Fales HM, Kaufman J, Stahl SJ, Wingfield P, Yarchoan R.
    J Virol. 77: 3319-25, 2003. [ Journal Article ]
  3. Davis DA, Newcomb FM, Starke DW, Ott DE, Mieyal JJ, Yarchoan R.
    J. Biol. Chem.. 272: 25935-40, 1997. [ Journal Article ]
  4. Davis DA, Rinderknecht AS, Zoeteweij JP, Aoki Y, Read-Connole EL, Tosato G, Blauvelt A, Yarchoan R.
    Blood. 97: 3244-50, 2001. [ Journal Article ]
  5. Davis DA, Singer KE, Reynolds IP, Haque M, Yarchoan R.
    Cancer Res.. 67: 7003-10, 2007. [ Journal Article ]

Biography

Masters of Science, Biochemistry-University of Vermont 1987 PhD, Biochemistry-Purdue University 1992 PostDoc 1992-1995, NHLBI, NIH Staff Scientist-1996-present