News & Publications
Life without a stomach: a patient's perspective on preventative surgery, advancing stomach cancer research
NIH Clinical Center News, Winter 2018
When David Fogel had a stomach, his fast-paced life was focused on expanding Bump 'n Grind, his coffee shop and record store in downtown Silver Spring, and managing a creative agency and two co-working spaces. Incorporated into his busy schedule was raising his two little sons with his wife. Read more...
November 30, 2017
On Wednesday, Nov. 29, 2017, NIH Foregut Team members presented information and answered questions during a webinar on stomach cancer treatment options. Jeremy Davis, M.D., Staff Clinician in the CCR Thoracic and Gastrointestinal Oncology Branch, and Theo Heller, M.D., Senior Investigator in the National Institute of Diabetes and Digestive and Kidney Diseases, joined David Fogel, a recent total gastrectomy patient, to discuss the latest advancements in treatment. The webinar, “Navigating New Treatment Options for Gastric Cancer: Reaching above and beyond the standard of care,” was facilitated by the NIH Clinical Center and Inspire, a social network for health that connects patients and caregivers in a safe, permission-based manner. Access the recorded webinar.
September 12, 2017
R. Taylor Ripley, M.D., of the Thoracic and Gastrointestinal Oncology Branch is leading a study to determine whether metabolomic signatures or BH3 profiling in biopsy tissues can identify patients who will likely respond well to pre-surgical treatment. Learn more...
May 1, 2017
A new clinical trial is open to test a two-part treatment for stomach cancer that has spread to the peritoneum. Learn more...
March 30, 2017
Nineteen-year-old Joel Rodriguez didn’t think he would be able to eat again. However, a collaboration between surgeons in the Center for Cancer Research (CCR) and the National Institute of Allergy and Infectious Diseases (NIAID) gave that back to him. Rodriquez and his treatment team celebrated the success of their operation with Rodriguez’s food of choice — cheeseburgers and French fries — in his hospital room. Read More...
March 27, 2017
The new NIH Foregut Team includes experts from a wide range of disciplines. The team hopes to give patients the best possible outcome by working together and sharing their expertise. Read more...
New clinical trial combines LMB-100 with nab-paclitaxel for metastatic or locally advanced pancreatic cancer
July 8, 2016
Christine Campo Alewine, Lasker Scholar, in the Laboratory of Molecular Biology is conducting a clinical study for patients with pancreatic cancer using a new immunotoxin drug, called LMB-100. It is a targeted immunotherapy that delivers a toxin to cancer cells that make a protein called mesothelin that is made by most pancreatic cancers. Learn more...
Jeremy Davis featured in Wall Street Journal article on preventive surgery for stomach cancer
March 13, 2018
The Wall Street Journal recently reported on the growing number of individuals with a family history of stomach cancer who choose to undergo genetic testing or total stomach removal as a preventive measure. The article features Jeremy Davis, M.D., Staff Clinician in the Thoracic and Gastrointestinal Oncology Branch and Surgeon-in-Chief at the NIH Clinical Center, who notes that researchers have quite a bit to learn about a mutation in the CDH1 gene linked to an increased risk of a certain type of stomach cancer. Read the full article...
Selected Recent Publications
Bile acid and cigarette smoke enhance the aggressive phenotype of esophageal adenocarcinoma cells by downregulation of the mitochondrial uncoupling protein-2. Xu Y, Feingold PL, Surman DR, Brown K, Xi S, Davis JL, Hernandez J, Schrump DS, Ripley RT. Oncotarget 2017 Nov 10;8(60):101057-101071.
Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes. Kolyvas E, Rudloff M, Poruchynsky M, Landsman R, Hollevoet K, Venzon D, Alewine C. Oncotarget 2017 Feb 7;8(6):9189-9199.
Single cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma. Zheng H, Pomyen Y, Hernandez MO, Li C, Livak F, Tang W, Dang H, Greten TF, Davis JL, Zhao Y, Mehta M, Levin Y, Shetty J, Tran B, Budhu A, Wang XW. Hepatology. 2018 Jan 9. doi: 10.1002/hep.29778. [Epub ahead of print].
Heated intraperitoneal chemotherapy and gastrectomy for gastric cancer in the U.S.: the time is now. Brown ZJ, Hernandez JM, Ripley RT, Davis JL. J Gastrointest Oncol. 2017 Dec;8(6):1109-1113. doi: 10.21037/jgo.2017.09.01. Review.