Chin-Hsien (Emily)  Tai
Chin-Hsien (Emily) Tai
Staff Scientist

Center for Cancer Research
National Cancer Institute

Bldg. 37, Rm 5120
Bethesda, MD 20892-4262
301-402-0437

Our lab focused on developing programs to compare protein structures, to generate more accurate alignments and to parse protein structures into domains in a reliable and rational fashion. We also have interests in studying protein structures with internal symmetry. The long term goal is to discover the sequence-structure relation, the relation between the active sites and the structural types and the evolution of the structure types.

Areas of Expertise
protein structures

Our lab focused on developing programs to compare protein structures, to generate more accurate alignments and to parse protein structures into domains in a reliable and rational fashion. We also have interests in studying protein structures with internal symmetry. The long term goal is to discover the sequence-structure relation, the relation between the active sites and the structural types and the evolution of the structure types. We were assessors in the 6th Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP6) for 'Prediction of New Folds' and 'Domain Prediction' categories in 2004. Once again, we were invited to assess 'Template free modeling', 'CASP ROLL', and 'Contact-Assisted modeling' in 2012 CASP10. Recently, we developed new algorithm for predicting B cell epitope hot spot residues and are also working on evaluating T cell epitope prediction.

Selected Publications
  1. Tai CH, Paul R, Dukka K, Shilling JD, Lee B.
    Nucleic Acids Res.. 2014. [ Journal Article ]
  2. Tai CH, Bai H, Taylor TJ, Lee B.
    Proteins. 82 Suppl 2: 57-83, 2014. [ Journal Article ]
  3. Taylor TJ, Tai CH, Huang YJ, Block J, Bai H, Kryshtafovych A, Montelione GT, Lee B.
    Proteins. 82 Suppl 2: 14-25, 2014. [ Journal Article ]
  4. Taylor TJ, Bai H, Tai CH, Lee B.
    Proteins. 82 Suppl 2: 84-97, 2014. [ Journal Article ]
  5. Samson F, Shrager R, Tai CH, Sam V, Lee B, Munson PJ, Gibrat JF, Garnier J.
    Bioinformatics. 28: 1040-1, 2012. [ Journal Article ]

Emily obtained her MS in Immunology from National Taiwan University and another MS in Computer and Information Science from New Jersey Institute of Technology. Before joining NCI, she worked in Goldman, Sachs & Co. in New York City and Goldman, Sachs International Ltd. in London as Programmer Analyst at Information Technology Division for 3 years.

Summary

Our lab focused on developing programs to compare protein structures, to generate more accurate alignments and to parse protein structures into domains in a reliable and rational fashion. We also have interests in studying protein structures with internal symmetry. The long term goal is to discover the sequence-structure relation, the relation between the active sites and the structural types and the evolution of the structure types.

Areas of Expertise
protein structures

Research

Our lab focused on developing programs to compare protein structures, to generate more accurate alignments and to parse protein structures into domains in a reliable and rational fashion. We also have interests in studying protein structures with internal symmetry. The long term goal is to discover the sequence-structure relation, the relation between the active sites and the structural types and the evolution of the structure types. We were assessors in the 6th Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP6) for 'Prediction of New Folds' and 'Domain Prediction' categories in 2004. Once again, we were invited to assess 'Template free modeling', 'CASP ROLL', and 'Contact-Assisted modeling' in 2012 CASP10. Recently, we developed new algorithm for predicting B cell epitope hot spot residues and are also working on evaluating T cell epitope prediction.

Publications

Selected Publications
  1. Tai CH, Paul R, Dukka K, Shilling JD, Lee B.
    Nucleic Acids Res.. 2014. [ Journal Article ]
  2. Tai CH, Bai H, Taylor TJ, Lee B.
    Proteins. 82 Suppl 2: 57-83, 2014. [ Journal Article ]
  3. Taylor TJ, Tai CH, Huang YJ, Block J, Bai H, Kryshtafovych A, Montelione GT, Lee B.
    Proteins. 82 Suppl 2: 14-25, 2014. [ Journal Article ]
  4. Taylor TJ, Bai H, Tai CH, Lee B.
    Proteins. 82 Suppl 2: 84-97, 2014. [ Journal Article ]
  5. Samson F, Shrager R, Tai CH, Sam V, Lee B, Munson PJ, Gibrat JF, Garnier J.
    Bioinformatics. 28: 1040-1, 2012. [ Journal Article ]

Biography

Emily obtained her MS in Immunology from National Taiwan University and another MS in Computer and Information Science from New Jersey Institute of Technology. Before joining NCI, she worked in Goldman, Sachs & Co. in New York City and Goldman, Sachs International Ltd. in London as Programmer Analyst at Information Technology Division for 3 years.