Joel P. Schneider, Ph.D.

Joel P. Schneider, Ph.D.
Chief
Chemical Biology Laboratory
Senior Investigator
Head, Peptide Design and Materials Section
CCR Deputy Director

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Link to additional information about Dr. Schneider’s research.

Areas of Expertise

1) peptides, 2) materials science, 3) hydrogels, 4) chemical biology,5) organic
synthesis, 6) tissue engineering

Contact Info

Joel P. Schneider, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 376, Room 104
Frederick, MD 21702-1201
Ph: 301-846-5954
Joel.Schneider@nih.gov

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Chemical Biology, Molecular Biology and Biochemistry
View Dr. Schneider's Complete Bibliography at NCBI.

Selected Key Publications

  1. Uncoupling the folding-function paradigm of lytic peptides to deliver impermeable inhibitors of intracellular protein-protein interactions.
    Stephen E. Miller, Kohei Tsuji, Terrance R. Burke Jr., and Joel P. Schneider
    J. Am. Chem. Soc.. 142: 19950, 2020. [ Journal Article ]
  2. Multiphase assembly of small molecule microcrystalline peptide hydrogel allows immunomodulatory combination therapy for long-term heart transplant survival.
    Poulami Majumder, Yichuan Zhang, Marcos Iglesias, Lixin Fan, James A. Kelley, Caroline Andrews, Nimit Patel, Jason R. Stagno, Byoung Chol Oh, Georg Furtmueller, Yun-Xing Wang, Gerald Brandacher, Giorgio Raimondi, Joel P. Schneider
    Small. 16: 1-12, 2020. [ Journal Article ]
  3. Electrostatically-driven quanidinium interaction domains that control hydrogel-mediated protein delivery in vivo.
    Stephen E. Miller, Yuji Yamada, Nimit Patel, Ernesto Suarez, Caroline Andrews, Steven Tau, Brain T. Luke, Raul E. Cachau, and Joel P. Schneider
    ACS Central Science. 5: 1750, 2019. [ Journal Article ]
  4. Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma.
    Poulami Majumder, Ulrich Baxa, Scott T. R. Walsh, Joel P. Schneider
    Angew Chem Int Ed. 57(46): 15040-44, 2018. [ Journal Article ]
  5. New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
    Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK.
    Nature Nanotechnology. 11: 95, 2016. [ Journal Article ]

Dr. Schneider received his Ph.D. in Organic Chemistry from Texas A&M University with Jeffery Kelly and then went on to the University of Pennsylvania School of Medicine, Department of Biochemistry and Biophysics where he was a George W. Raiziss Fellow with William DeGrado studying protein design. In 1999, he began his independent career at the University of Delaware as an assistant professor of Chemistry and Biochemistry and was promoted to associate and then full professor in 2009 with a secondary appointment in Materials Science and Engineering. He joined the NCI in 2010 as lab Chief of the newly established Chemical Biology Laboratory and was later appointed Deputy Director in 2015.  He currently serves as Executive Editor of Biopolymers-Peptide Science, the journal of the American Peptide Society.

Name Position
Gali Fichman Ph.D. Postdoctoral Fellow (Visiting)
Chen Liang Ph.D. Postdoctoral Fellow (Visiting)
Stephen Miller Ph.D. Postdoctoral Fellow (CRTA)
Gary T. Pauly, Ph.D. Staff Scientist
Scott Walsh, Ph.D. Staff Scientist
Xiaoyi Wang Ph.D. Postdoctoral Fellow (Visiting)