Postbaccalaureate Fellow - CAR-T immunotherapy, antibody engineering

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

A Postbaccalaureate Fellow position is available in Dr. Mitchell Ho's laboratory at the Center for Cancer Research (CCR), National Cancer Institute (NCI) in Bethesda, Maryland, USA. For more information visit the Ho lab website:

Our laboratory studies cell surface proteins such as glypicans, including GPC1, GPC2, and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors, such as liver cancer, pancreatic cancer, and childhood cancers. We have utilized molecular and cellular biology, computational structure modeling, RNA sequencing (RNA-seq), and mouse tumor models. We have developed single-domain antibody (nanobody) technology, isolated antibodies targeting tumor-specific epitopes, and engineered CAR or TCR constructs to design novel T cell-based immunotherapies. Some of our research has the potential for direct clinical application.

Two recent papers published by our lab:

Qualifications and Job Details

Degree Required
B.S./B.A. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
Full-time (In-Person)
US Citizenship required

Required and Preferred Skills

Required Skills

Candidates should have received a B.S./B.A. (GPA > 3.6) in biochemistry, chemistry, biomedical engineering, or a related discipline. The candidate should be self-motivated, enthusiastic, and have excellent organizational skills with laboratory research experience. Excellent oral and written communication skills are also required.

Preferred Skills

Laboratory experience in molecular biology, cell biology, and biochemistry techniques is a plus. Individuals with a passion for science and a capacity to work in a highly collaborative environment are encouraged to apply.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • 3 References
  • Cover Letter
Contact Information
Contact Name
Dr. Mitchell Ho
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.