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Alexander  Wlodawer, Ph.D.

Alexander Wlodawer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Structural Biology

RESEARCH SUMMARY

Dr. Wlodawer is a structural biologist investigating the relationship between protein structure and function, mainly by high-resolution X-ray diffraction. Some of his areas of interest include elucidating structural features of macromolecules that could explain their importance to understanding cancer and AIDS. Examples include proteases, viral glycoproteins and enzymes, and proteins that are part of cell signaling systems, in particular cytokines and their receptors. He is also active in the development of crystallographic methods.

Areas of Expertise

Protein Crystallography
Expression and Purification of Proteins
Development of Crystallographic Techniques
Analysis of The Quality of Crystal Structures
Proteolytic Enzymes

Publications

Selected Key Publications

Crystal structure of a retroviral protease proves relationship to aspartic protease family

Miller M, Jaskólski M, Rao JK, Leis J, Wlodawer A.
Nature. 337: 576-9, 1989. [ Journal Article ]

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

Wlodawer A, Miller M, Jaskólski M, Sathyanarayana BK, Baldwin E, Weber IT, Selk LM, Clawson L, Schneider J, Kent SB.
Science. 245: 616-21, 1989. [ Journal Article ]

Crystal structure of interleukin 8: symbiosis of NMR and crystallography

Baldwin ET, Weber IT, St. Charles R, Xuan J-C, Appella E, Yamada M, Matsushima K, Edwards BFP, Clore GM, Gronenborn AM, and Wlodawer A.
Proc. Natl. Acad. Sci. U.S.A. 88: 502-6, 1991. [ Journal Article ]

High-resolution structure of the catalytic domain of avian sarcoma virus integrase

Bujacz G, Jaskólski M, Alexandratos J, Wlodawer A, Merkel G, Katz RA, Skalka AM.
J. Mol. Biol. 253: 333-46, 1995. [ Journal Article ]

Crystal structure of XMRV protease differs from the structures of other retropepsins

Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A.
Nat. Struct. Mol. Biol. 18: 227-9, 2011. [ Journal Article ]

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Team

Photo of Dr. Ishan Rathore of NCI-CCR-CSB-PSS
Postdoctoral Fellow
Ishan Rathore, Ph.D.
Photo of Dr. Di Zahang of NCI-CCR-CSB-PSS
Research Assistant
Di Zhang, Ph.D.

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