Aleksandra M. Michalowski, M.Sc., Ph.D.
Aleksandra M. Michalowski, M.Sc., Ph.D.
Staff Scientist

Dr. Michalowski develops biostatistical and bioinformatic approaches for the design and analysis of preclinical cancer research experiments. Her primary focus is genomic studies, which include integration and biological interpretation of large-scale transcriptional signatures from cancer models and patients across a variety of cancer types (multiple myeloma, breast cancer, melanoma and non-melanoma skin cancers, prostate cancer, and lung cancer), modeling of genomic networks, analysis workflows for next-generation sequencing data, and preclinical development of predictive signatures for cancer treatments. Her most recent project involves development of new algorithms for screening of anti-cancer synergistic drug combinations based on high-throughput in vitro assays.

Areas of Expertise
biostatistics, bioinformatics, preclinical

Contact Info

Aleksandra M. Michalowski, M.Sc., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 3134B
Bethesda, MD 20892
301.496.4988
MichaloA@mail.nih.gov

Dr. Michalowski develops biostatistical and bioinformatic approaches for the design and analysis of preclinical cancer research experiments. Her primary focus is genomic studies, which include integration and biological interpretation of large-scale transcriptional signatures from cancer models and patients across a variety of cancer types (multiple myeloma, breast cancer, melanoma and non-melanoma skin cancers, prostate cancer, and lung cancer), modeling of genomic networks, analysis workflows for next-generation sequencing data, and preclinical development of predictive signatures for cancer treatments. Her most recent project involves development of new algorithms for screening of anti-cancer synergistic drug combinations based on high-throughput in vitro assays.

Dr. Michalowski conducts collaborative research within the Laboratory of Cancer Biology and Genetics, the Biometric Research Branch (DCTD), and the National Center for Advancing Translational Sciences (NCATS) at NIH. Inventions Gene expression signatures of neoplasm responsiveness to therapy. PCT Application No. PCT/US2012/064693 NIH (DHHS) Reference No. E-013-2012/0-PCT-02 National stage filing in progress.

Selected Publications
  1. Simmons JK, Patel J, Michalowski A, Zhang S, Wei BR, Sullivan P, Gamache B, Felsenstein K, Kuehl WM, Simpson RM, Zingone A, Landgren O, Mock BA.
    Mol Oncol. 8: 261-72, 2014. [ Journal Article ]
  2. Bennett CN, Tomlinson CC, Michalowski AM, Chu IM, Luger D, Mittereder LR, Aprelikova O, Shou J, Piwinica-Worms H, Caplen NJ, Hollingshead MG, Green JE.
    Breast Cancer Res.. 14: R109, 2012. [ Journal Article ]
  3. Chu IM, Michalowski AM, Hoenerhoff M, Szauter KM, Luger D, Sato M, Flanders K, Oshima A, Csiszar K, Green JE.
    Oncogene. 31: 2017-27, 2012. [ Journal Article ]
  4. Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM.
    J Pathol Inform. 3: 18, 2012. [ Journal Article ]
  5. Lee KH, Li M, Michalowski AM, Zhang X, Liao H, Chen L, Xu Y, Wu X, Huang J.
    Proc. Natl. Acad. Sci. U.S.A.. 107: 69-74, 2010. [ Journal Article ]

Dr. Aleksandra M. Michalowski received her M.Sc. and Ph.D. in biological sciences from the University of Adam Mickiewicz (UAM) in Poznan, Poland. She completed her postdoctoral training under Dr. Richard Simon at the Biometric Research Branch, Division of Cancer Treatment and Diagnosis, NCI, where she conducted research focusing on statistical analysis and computational programming in cancer genomics. Dr. Michalowski joined the Laboratory of Cancer Biology and Genetics as a staff scientist in 2005.

Research

Dr. Michalowski develops biostatistical and bioinformatic approaches for the design and analysis of preclinical cancer research experiments. Her primary focus is genomic studies, which include integration and biological interpretation of large-scale transcriptional signatures from cancer models and patients across a variety of cancer types (multiple myeloma, breast cancer, melanoma and non-melanoma skin cancers, prostate cancer, and lung cancer), modeling of genomic networks, analysis workflows for next-generation sequencing data, and preclinical development of predictive signatures for cancer treatments. Her most recent project involves development of new algorithms for screening of anti-cancer synergistic drug combinations based on high-throughput in vitro assays.

Dr. Michalowski conducts collaborative research within the Laboratory of Cancer Biology and Genetics, the Biometric Research Branch (DCTD), and the National Center for Advancing Translational Sciences (NCATS) at NIH. Inventions Gene expression signatures of neoplasm responsiveness to therapy. PCT Application No. PCT/US2012/064693 NIH (DHHS) Reference No. E-013-2012/0-PCT-02 National stage filing in progress.

Publications

Selected Publications
  1. Simmons JK, Patel J, Michalowski A, Zhang S, Wei BR, Sullivan P, Gamache B, Felsenstein K, Kuehl WM, Simpson RM, Zingone A, Landgren O, Mock BA.
    Mol Oncol. 8: 261-72, 2014. [ Journal Article ]
  2. Bennett CN, Tomlinson CC, Michalowski AM, Chu IM, Luger D, Mittereder LR, Aprelikova O, Shou J, Piwinica-Worms H, Caplen NJ, Hollingshead MG, Green JE.
    Breast Cancer Res.. 14: R109, 2012. [ Journal Article ]
  3. Chu IM, Michalowski AM, Hoenerhoff M, Szauter KM, Luger D, Sato M, Flanders K, Oshima A, Csiszar K, Green JE.
    Oncogene. 31: 2017-27, 2012. [ Journal Article ]
  4. Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM.
    J Pathol Inform. 3: 18, 2012. [ Journal Article ]
  5. Lee KH, Li M, Michalowski AM, Zhang X, Liao H, Chen L, Xu Y, Wu X, Huang J.
    Proc. Natl. Acad. Sci. U.S.A.. 107: 69-74, 2010. [ Journal Article ]

Biography

Dr. Aleksandra M. Michalowski received her M.Sc. and Ph.D. in biological sciences from the University of Adam Mickiewicz (UAM) in Poznan, Poland. She completed her postdoctoral training under Dr. Richard Simon at the Biometric Research Branch, Division of Cancer Treatment and Diagnosis, NCI, where she conducted research focusing on statistical analysis and computational programming in cancer genomics. Dr. Michalowski joined the Laboratory of Cancer Biology and Genetics as a staff scientist in 2005.