Yoshimi Endo Greer, M.D., Ph.D.

Yoshimi Endo Greer, M.D., Ph.D.
Staff Scientist

Dr. Yoshimi E. Greer has extensive experience in cell biology, molecular biology, biochemistry and oncology. Her recent research focuses are 1) TRAIL-induced cell death, and 2) mitochondria in cancer. She is exploring potential clinical applications utilizing those mechanisms in cancer treatment. One of her studies has recently contributed to launch clinical trials in breast and endometrial cancers at NCI. She is always seeking exciting collaborations across the NIH campus to promote science discovery in cancer field.

Areas of Expertise
1) breast cancer, 2) cell death, 3) TRAIL/Death Receptor, 4) mitochondria, 5) signal transduction

Contact Info

Yoshimi Endo Greer, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building.10, Room4B50
Bethesda, MD 20892-4256
Ph: 240-858-3275
greery@mail.nih.gov
Scientific Focus Areas:
Cancer Biology, Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry

Selected Publications

  1. Yoshimi Endo Greer, Natalie Porat-Shliom, Kunio Nagashima, Christina Stuelten, Dan Crooks, Vishal N. Koparde, Samuel F. Gilbert, Celia Islam, Ashley Ubaldini, Yun Ji, Luca Gattinoni, Ferri Soheilian, Xiantao Wang, Markus Hafner, Jyoti Shetty, Bao Tran, Parthav Jailwala, Maggie Cam, Martin Lang, Donna Voeller, William C. Reinhold, Vinodh Rajapakse, Yves Pommier, Roberto Weigert, W. Marston Linehan and Stanley Lipkowitz
    Oncotarget. 9: 18454-18479, 2018. [ Journal Article ]
  2. Endo Greer Y, Lipkowitz S.
    Science Signaling. 9: 415, 2016. [ Journal Article ]
  3. Dine JL, O'Sullivan CC, Voeller D, Greer YE, Chavez KJ, Conway CM, Sinclair S, Stone B, Amiri-Kordestani L, Merchant AS, Hewitt SM, Steinberg SM, Swain SM, Lipkowitz S.
    Breast Cancer Res Treat. 155(2): 235-51, 2016. [ Journal Article ]
  4. Greer YE, Lipkowitz S.
    Oncoscience. 2(2): 75-6, 2015. [ Journal Article ]
  5. Yoshimi Endo Greer, Bo Gao, Yingzi Yang, Andre Nussenzweig, Jeffrey S. Rubin
    PLoS One. 12(1): e0170903, 2017. [ Journal Article ]

Dr. Yoshimi E. Greer obtained her M.D. in 1994 from Tohoku University School of Medicine, Japan. She conducted clinical residency training in internal medicine for 5 years. In 1999, she received Ph.D. in renal physiology the Graduate School of Tohoku University, Japan. 

In 1998, she joined Dr. Josephine P. Briggs' lab at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as a postdoctoral fellow. In 2001, she transferred to Dr. Jeffrey S. Rubin's lab in NCI, and studied Wnt signaling in cancer. In 2004, she joined Lombardi Comprehensive Cancer Center, Georgetown University Medical School in Washington DC as a research instructor, and studied breast cancer.

In 2006, she returned to NCI as a research fellow, and continued Wnt signaling research in cancer. In 2009, she became a staff scientist in the Laboratory of Cellular and Molecular Biology (LCMB), CCR.

In 2014, she joined Dr. Stan Lipkowitz’s lab to explore her great interest in oncology and translational research in breast cancer. Her current research focuses are 1) to develop breast cancer treatment strategies utilizing TRAIL/Death Receptor, 2) to investigate the role of mitochondria in cancer as a therapeutic target.