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Philip  Tofilon, Ph.D.

Philip Tofilon, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Radiation Oncology Branch

RESEARCH SUMMARY

Dr. Tofilon’s research is aimed at understanding the molecular determinants of cellular radiosensitivity with the ultimate goal of developing target based radiosensitizing agents. Over the last several years studies in his lab have focused on two specific projects: the radiation-induced translational control of gene expression and the microenvironmental regulation of glioblastoma radioresponse.

Areas of Expertise

Radiation Biology
Translational Control of Gene Expression
Radiation Sensitizers
mTOR

Publications

Selected Key Publications

The Olfactory Bulb Provides a Radioresistant Niche for Glioblastoma Cells

Timme CR, Degorre-Kerbaul C, McAbee JH, Rath BH, Wu X, Camphausen K, Tofilon PJ.
Int J Radiat Oncol Biol Phys. 107(1): 194-201, 2020. [ Journal Article ]

Radiation Drives the Evolution of Orthotopic Xenografts Initiated from Glioblastoma Stem-like Cells

McAbee JH, Rath BH, Valdez K, Young DL, Wu X, Shankavaram UT, Camphausen K, Tofilon PJ.
Cancer Res. 79(23): 6032-43, 2019. [ Journal Article ]

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS.
Cancer Res. 79(7): 1438-50, 2019. [ Journal Article ]

Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells

Wahba A, Rath BH, Bisht K, Camphausen K, Tofilon PJ.
Cancer Res. 76(10): 3078-87, 2016. [ Journal Article ]

The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells

Hayman TJ, Wahba A, Rath BH, Bae H, Kramp T, Shankavaram UT, Camphausen K, Tofilon PJ.
Clin. Cancer Res. 20: 110-9, 2014. [ Journal Article ]

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Team

Postdoctoral Fellow (CRTA)
Stacey Lehman, Ph.D.
Predoctoral Fellow (Medical Student)
Joseph McAbee
Postdoctoral Fellow (CRTA)
Barbara Rath, Ph.D.
Postdoctoral Fellow (CRTA)
Cindy Timme, Ph.D.
Postbaccalaureate Fellow (CRTA)
Theresa Wechsler

News

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