David A. Ball, Ph.D.

Staff Scientist

Team Member of:

Dr. Ball is a Staff Scientist in the Optical Microscopy Core (OMC) which specializes in live-cell imaging, and quantitative biophysical methods, such as Single-molecule Tracking (SMT), Förster Resonance Energy Transfer (FRET), and Fluorescence Recovery after Photobleaching (FRAP). His primary role is to develop and maintain custom microscopes and train investigators on their use. Dr. Ball’s research interests include the development of custom microscopes, software and models to extract and interpret biophysical parameters in cellular processes. 

Areas of Expertise
1) Microscope Development; 2) Fluorescence Imaging; 3) Single-molecule Tracking; 4) Stochastic Modeling

Contact Info

David A. Ball, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room C615
Bethesda, MD 20892
Ph: 240-760-7023
ballda@mail.nih.gov

Dr. Ball is a Staff Scientist in the Optical Microscopy Core (OMC) which specializes in live-cell imaging, and quantitative biophysical methods, such as Single-molecule Tracking (SMT), Förster Resonance Energy Transfer (FRET), and Fluorescence Recovery after Photobleaching (FRAP). His primary role is to develop and maintain custom microscopes and train investigators on their use. Dr. Ball’s research interests include the development of custom microscopes, software and models to extract and interpret biophysical parameters in cellular processes.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cell Biology

Selected Recent Publications

  1. V Paakinaho, DM Presman, DA Ball, TA Johnson, RL Schiltz, P Levitt, D Mazza, T Morisaki, TS Karpova, and GL Hager
    Nat Commun. 8: 15896, 2017. [ Journal Article ]
  2. DM Presman, DA Ball, V Paakinaho, JB Grimm, LD Lavis, TS Karpova, and GL Hager
    Methods. 123: 76-88, 2017. [ Journal Article ]
  3. DA Vargas-Inchaustegui, A Demers, JM Shaw, G Kang, DA Ball, I Tuero, T Musich, V Mohanram, T Demberg, TS Karpova, Q Li, and M Robert-Guroff
    J Immunol. 196: 1700-1710, 2016. [ Journal Article ]
  4. DA Ball, GD Mehta, R Salomon-Kent, D Mazza, T Morisaki, F Mueller, JG McNally, and TS Karpova
    Nucleic Acids Res. 44(21): e160, 2016. [ Journal Article ]
  5. EE Swinstead, TB Miranda, V Paakinaho, S Baek, I Goldstein, M Hawkins, TS Karpova, DA Ball, D Mazza, LD Lavis, JB Grimm, T Morisaki, L Grøntved, DM Presman, and GL Hager
    Cell. 165: 593-605, 2016. [ Journal Article ]

Dr. Ball completed his B.S. in Physics at the University of Albany in 2000. He then went on to earn a Ph.D in Physics at the University of Tennessee in 2006, where he worked on improving the use of fluorescence correlation spectroscopy for pharmaceutical drug discovery using an applied flow. Dr. Ball then joined the laboratory of Jean Peccoud at Virginia Tech, where in collaboration with John Tyson, we performed live imaging of cell cycle regulators in budding yeast. Dr. Ball joined the Optical Microscopy Core in 2015.