Hao-Wei Wang, M.D., Ph.D.

Hao-Wei Wang, M.D., Ph.D.
Assistant Research Physician
Laboratory of Pathology
Hematopathologist

Dr. Wang's primary research interests include the pathogenesis of lymphomas and biomarkers in hematologic malignancies. His research is focused on the genetic alterations and resultant cellular changes that lead to lymphomagenesis. He is also interested in the pathogenesis of virus (e.g., Kaposi sarcoma herpesvirus) associated lymphoproliferative disorders. Additionally, he seeks to advance the diagnosis and minimal residual diseases detection of hematologic malignancies by incorporating new biomarkers in multiparametric flow cytometry.

Areas of Expertise

1) hematopathology, 2) flow cytometry, 3) lymphomas

Contact Info

Hao-Wei Wang, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 3S235F
Bethesda, MD 20892
Ph: 301-480-8043
hao-wei.wang@nih.gov
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Dr. Wang is a hematopathologist in the Laboratory of Pathology. He has been actively working on the genetic and epigenetic landscapes of T-cell lymphomas. He also has expertise in virus-associated lymphoproliferative disorders, such as Kaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease and primary effusion lymphoma. He is developing new tools to improve the diagnosis and stratification of these diseases. He is also developing new strategies in multiparametric flow cytometry for detection of minimal residual diseases, characterization of therapeutic targets and monitoring of adoptively transferred immune cells in the era of cancer immunotherapy.

NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Clinical Research, Immunology, Molecular Biology and Biochemistry

Selected Recent Publications

  1. Molecular assessment of clonality in lymphoid neoplasms.
    Wang HW and Raffeld M
    Seminars in Hematology. in press, 2018.
  2. Diagnosis of Hodgkin lymphoma in the modern era.
    Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES.
    British Journal of Haematology. Epub ahead of print, 2018. [ Journal Article ]
  3. STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation.
    Yan D, Wang HW, Bowman RL, Joyce JA.
    Cell Reports. 16(11): 2914-2927, 2016. [ Journal Article ]
  4. Multicentric Castleman Disease: Where are we now? .
    Wang HW, Pittaluga S, Jaffe ES.
    Seminars in Diagnostic Pathology. 33(5): 294-306, 2016. [ Journal Article ]
  5. Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions.
    Wang HW and Joyce JA
    Cell Cycle. 9(24): 4824-4835, 2010. [ Journal Article ]

Dr. Wang received his M.D. from the National Taiwan University and his Ph.D. in Cell Biology from the Weill Cornell Medicine of Cornell University. He completed his residency training in anatomic pathology and fellowship in hematopathology at the NCI, and joined the Laboratory of Pathology as a Staff Clinician in 2018.