Breadcrumb

Joseph M. Ziegelbauer, Ph.D.

Joseph M. Ziegelbauer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Head, Viral Non-coding RNA Section

RESEARCH SUMMARY

Our previous research discovered functions of viral microRNAs related to inhibiting apoptosis, evading immune responses, and promoting angiogenesis. Ongoing research focuses on networks and pathways redundantly targeted by multiple viral microRNAs and circular RNAs. In collaboration with Drs. Yarchoan, Ramaswami, Lurain, and Krug in HAMB, we have been investigating human and viral gene expression patterns in normal tissue, in Kaposi sarcoma (KS), and other KSHV-infected pathological tissues. We are using a variety of expression profiling techniques and functional studies to determine the importance of these gene expression patterns. These studies will lead to the discovery of new therapeutic targets for inhibiting viral oncogenesis.

Areas of Expertise

Kaposi's Sarcoma-Associated Herpesvirus (KSHV)
Virus-Host Interactions

Publications

Selected Key Publications

Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses

Dremel SE, Koparde VN, Arbuckle JH, Hogan CH, Kristie TM, Krug LT, Conrad NK, Ziegelbauer JM
EMBO J. 2025. [ Journal Article ]

A virus-induced circular RNA maintains latent infection of Kaposi’s sarcoma herpesvirus

Tagawa T, Oh D, Dremel S, Mahesh G, Koparde VN, Duncan G, Andresson T, Ziegelbauer JM.
PNAS. 2023. [ Journal Article ]

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Ramaswami R, Tagawa T, Mahesh G, Serquina A, Koparde V, Lurain K, Dremel S, Li X, Mungale A, Beran A, Ohler ZW, Bassel L, Warner A, Mangusan R, Widell A, Ekwede I, Krug LT, Uldrick TS, Yarchoan R, Ziegelbauer JM.
Journal of Translational Medicine. 2023. [ Journal Article ]

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Sequiña AP, Lurain K, Ramaswami R, Uldrick TS, Yarchoan R, Ziegelbauer JM
Proc Natl Acad Sci U S A. 2018. [ Journal Article ]

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

Serquiña AKP, Kambach DM, Sarker O, Ziegelbauer JM
MBio. 2017. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Non-coding RNAs and viruses Ph.D. or equivalent Joseph Ziegelbauer ziegelbauerjm@nih.gov

Team

Serquina, Anna, M.D., Ph.D.
Staff Scientist
Anna Serquina, M.D., Ph.D.
Ameera Mungale
Graduate student
Ameera Mungale
Daphne Knudsen-Palmer
Postdoctoral Fellow
Daphne Knudsen-Palmer, Ph.D.
Mahgol Behnia
Postdoctoral Fellow
Mahgol Behnia, Ph.D.

News

Learn more about CCR research advances, new discoveries and more
on our news section.

Alumni

Takanobu, Tagawa, Ph.D.
Takanobu, Tagawa, Ph.D.
Postdoctoral Fellow (Visiting)
Dremel, Sarah, Ph.D.
Dremel, Sarah, Ph.D.
Postdoctoral Fellow
Kook, Insun, Ph.D.
Kook, Insun, Ph.D.
Postdoctoral Fellow
Ramalingam, Dhivya, Ph.D.
Ramalingam, Dhivya, Ph.D.
Postdoctoral Fellow
Happel, Christine, Ph.D.
Happel, Christine, Ph.D.
Postdoctoral Fellow
Kieffer-Kwon, Philippe, Ph.D.
Kieffer-Kwon, Philippe, Ph.D.
Postdoctoral Fellow
Abend, Johanna, Ph.D.
Abend, Johanna, Ph.D.
Postdoctoral Fellow
Hernandez-Perez, Carmen
Hernandez-Perez, Carmen
Postbaccalaureate Fellow
Lee, Julie
Lee, Julie
Postbaccalaureate Fellow
Oh, Daniel
Oh, Daniel
Postbaccalaureate Fellow
Gallaher, Amelia
Gallaher, Amelia
Postbaccalaureate Fellow
Santos, Jerico
Santos, Jerico
Graduate Student