Yousuke Takahama, Ph.D.
The current interest of our laboratory is to understand molecular mechanisms (1) that build functionally competent thymus microenvironments, which are capable of supporting the production and selection of T cells, (2) that govern thymic selection to establish a functionally competent repertoire of mature T cells, and (3) that position developing T cells to localize within the thymus microenvironments for T cell repertoire formation.
1) thymus biology
2) thymic epithelial cells
3) thymus development
4) T cell development
5) T cell repertoire selection
6) T cell self-tolerance
The questions we would like to address in the next few years include how diverse microenvironments are formed in the thymus. How the thymic microenvironment contributes to the establishment of self-tolerance in T cells is another important question. We also would like to study the mechanisms involved in how developing T cells localize multiple thymic microenvironments for T cell repertoire formation and how positive selection in the thymic microenvironment fine-tunes antigen responsiveness in T cells.
Selected Recent Publications
- J Immunol. 200: 1382-1388 , 2018. [ Journal Article ]
- J Exp Med. 214: 1925-1935, 2017. [ Journal Article ]
- Nat Rev Immunol. 17: 295-305, 2017. [ Journal Article ]
- JCI Insight. 2: 93664, 2017. [ Journal Article ]
- Nat Commun. 8: 14419, 2017. [ Journal Article ]
Yousuke Takahama received his Ph.D. from Osaka University Graduate School of Medicine in Japan. He was a Visiting Fellow and Visiting Associate in the Experimental Immunology Branch, National Cancer Institute, where he studied thymocyte development and selection. He then started working on the biology of thymic microenvironments at Syntex Institute of Immunology and the University of Tsukuba in Japan. In 1999, he was appointed a Professor of Experimental Immunology, University of Tokushima. In 2018, he moved back to the United States to establish a new laboratory as a Senior Investigator in Experimental Immunology Branch, National Cancer Institute. He is a founding organizer of the Global Thymus Network. His main interests are the development and function of the thymus and thymic epithelial cells, especially with regard to the repertoire selection of T lymphocytes.
|Alison Jacques B.S.||Biologist (Contr.)|
|Amy Palin Ph.D.||Biologist (Contr.)|
|Yu Tanaka M.D.||Postdoctoral Fellow (Visiting)|
|Melina Frantzeskakis||Postbaccalaureate Fellow (CRTA)|
|Xuan Xie Ph.D.||Postdoctoral Fellow (Visiting)|