Christian T. Mayer, Ph.D.

Christian T. Mayer, Ph.D.
Investigator
NIH Stadtman Investigator

Dr. Mayer’s laboratory is interested in mechanisms of immune regulation, particularly the role of cell death in self-tolerance and adaptive immunity. His current research program focuses on unraveling the regulatory networks controlling cell death and determining their roles in immune cell development, differentiation and function in part by using a novel apoptosis reporter mouse he developed. These studies serve to increase our fundamental understanding of immune responses and of how defects in immune regulation might contribute to diseases. The long-term goals are to identify new therapeutic strategies to (1) inhibit unwanted immune responses, (2) enhance immune responses against tumors and pathogens.

Areas of Expertise

1) B lymphocyte differentiation and function, 2) antibodies, 3) self-tolerance and autoimmunity, 4) cell death, 5) immunology, 6) animal models

Contact Info

Christian T. Mayer, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 4B11
Bethesda, MD 20892-1360
Ph: 240-858-3340
christian.mayer@nih.gov

Self-tolerance regulation by apoptosis

A diverse set of T- and B cell receptors orchestrates adaptive immunity and immunological memory. In B lymphocytes, this diversity is created by two relatively random processes: variable diversity and joining gene segment (V(D)J) recombination in the bone marrow during development, and somatic hypermutation in germinal center B cells during adaptive immune responses. Self-reactive receptors are frequent byproducts of these processes and lymphocytes carrying those receptors must be controlled by various mechanisms in order to avoid the production of autoantibodies and the attack of the own body by the immune system. We will interrogate the specific role of apoptosis in controlling self-reactive lymphocytes by combining genetic tools with single-cell methods. Another goal is to determine at which lymphocyte differentiation- or activation stages this censoring occurs.  

Regulation of immune responses by cell death

Adaptive immunity relies on a tightly regulated control of the number and activity of different types of immune cells, and both parameters undergo dynamic changes during an immune response. One mechanism to regulate cell number and activity is cell death. While apoptosis is the best-known type of programmed cell death, it is becoming increasingly clear that other types of programmed cell death (e.g. pyroptosis, necroptosis) might also contribute to immune regulation. How each of these pathways are triggered in some cells while others survive within the same microenvironment is poorly understood, as is the exact functional role of each deletion mechanism. We aim to gain a better understanding of how different types of cell death in different types of cells regulate the kinetics, magnitude, longevity, or other characteristics of immune responses.

Disease and therapy relevance of immune regulation

While defective immune regulation can precipitate autoimmune diseases, excessive immune suppression can hinder immunity to microbes and tumor cells. The mechanisms and networks coordinating this delicate balance are insufficiently understood. We will determine if and how deregulated cell death is linked to inflammatory/autoimmune diseases and cancer, or to defective responses to vaccines and cancer immunotherapies. To achieve this goal, we employ animal disease models and novel genetic tools to manipulate cell death in a cell-type specific fashion. The long-term aim is to identify new immunoregulatory pathways that offer opportunities for targeted positive and negative regulation of immune responses.

NIH Scientific Focus Areas:
Cell Biology, Immunology, Molecular Biology and Biochemistry
  1. Mayer CT*, Nieke JP, Gazumyan A, Cipolla M, Wang Q, Oliveira TY, Ramos V, Monette S, Li QZ, Gershwin ME, Kashkar H, Nussenzweig MC*. (* Corresponding authors)
    Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2015372117: 2020. [ Journal Article ]
  2. Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC.
    Science. 358(6360): eaao2602, 2017. [ Journal Article ]
  3. Gitlin AD, Mayer CT, Oliveira TY, Shulman Z, Jones MJ, Koren A, Nussenzweig MC.
    Science. 349(6248): 643-6, 2015. [ Journal Article ]
  4. Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stüve P, Puttur F, Merad M, Sparwasser T.
    Blood. 124(20): 3081-91, 2014. [ Journal Article ]
  5. Klages K*, Mayer CT*, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T. (*equal contribution)
    Cancer Res. 70(20): 7788-99, 2010. [ Journal Article ]

Dr. Mayer received his Ph.D. in immunology from the Hannover Medical School, Germany, working on immune tolerance and regulatory T cell biology with Tim Sparwasser. He then joined Michel Nussenzweig’s laboratory as a postdoctoral fellow at The Rockefeller University, New York, where he developed new tools to study the regulation of antibody responses. Dr. Mayer started a position as a NIH Stadtman Tenure-Track Investigator at the Experimental Immunology Branch in 2020 where he explores immunoregulatory networks, particularly those involving cell death, in health and disease. He received several early career awards including the Fritz-and-Ursula-Melchers Postdoctoral Prize 2014 (German Society for Immunology), the Early Career Research Prize in Vaccinology 2018 (International Union of Immunological Societies) and the postdoctoral award in immunology 2018 by the Robert Koch Foundation.

Position Degree Required Contact Name E-mail Address
Post-doctoral Fellow - immunology, molecular biology Ph.D. or equivalent, M.D. or equivalent Christian Mayer christian.mayer@nih.gov
Name Position
Chris McNees Biologist (Contr.)
Mikala Willett Postbaccalaureate Fellow (CRTA)