Alfred Singer, M.D.

Chief
Senior Investigator
Head, Lymphocyte Development Section

Dr. Singer and his team seek to elucidate the molecular mechanism by which thymic selection generates an MHC-restricted T cell receptor repertoire that is coordinated with CD4 and CD8 coreceptor expression and appropriate T cell function.

Areas of Expertise
1) lymphocyte development, 2) immunology

Contact Info

Alfred Singer, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 4B36
Bethesda, MD 20892
Ph: 301-496-5461
singera@nih.gov

Lymphocyte Development

The differentiation of immature CD4+8+ (double positive, DP) thymocytes into mature T cells is the key event in T cell development as it gives rise to functional T cells and determines the mature T cell repertoire. Our research seeks to elucidate the molecular mechanism by which thymic selection generates an MHC-restricted T cell receptor repertoire that is coordinated with CD4 and CD8 coreceptor expression and appropriate T cell function.

Scientific Focus Areas:
Developmental Biology, Immunology
View Dr. Singer's PubMed Summary.

Selected Recent Publications

  1. Tai X, Singer A.
    Cell Cycle. 13: 501-2, 2014. [ Journal Article ]
  2. Mu J, Tai X, Iyer SS, Weissman JD, Singer A, Singer DS.
    J. Immunol. 192: 2892-903, 2014. [ Journal Article ]
  3. Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
    Immunity. 38: 1116-28, 2013. [ Journal Article ]
  4. Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
    Nat. Immunol. 14: 143-51, 2013. [ Journal Article ]
  5. Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
    Cell. 154: 1326-41, 2013. [ Journal Article ]

Dr. Singer received his M.D. from Columbia University and his clinical training at the Columbia-Presbyterian Medical Center. He was a fellow in immunology at the Rockefeller University before coming to the NCI. He is chief of the Experimental Immunology Branch and his research interests are in lymphocyte recognition and development, especially the molecular and cellular recognition signals that result in self/nonself discrimination during early development.

Name Position
Amala S. Alag Ph.D. Biologist
Sherif Badr Ph.D. Research Fellow
Abhisek Bhattacharya Ph.D. Postdoctoral Fellow (Visiting)
Ruth Etzensperger Ph.D. Research Fellow
Terry I. Guinter Biologist
Jeffrey A. Hammer Biologist
Alyssa Indart Postdoctoral Fellow (CRTA)
Tejas B. Kadakia Ph.D. Research Fellow
Michael J. Kruhlak, Ph.D. Facility Head
Marco Filipe Marques Craveiro Ph.D. Postdoctoral Fellow (Visiting)
Miho Shinzawa Ph.D. Postdoctoral Fellow (Visiting)
Xuguang Tai Ph.D. Staff Scientist
Francois Van Laethem Ph.D. Staff Scientist
Zhongmei Zhang Ph.D. Postdoctoral Fellow (Visiting)
Xuyu Zhou Laboratory Technician (Contr)