Nitin Roper, M.D., M.Sc.

Nitin Roper, M.D., M.Sc.
Assistant Clinical Investigator

Dr. Roper is a physician scientist with a research focus on high-grade neuroendocrine tumors, including small cell lung cancers, bladder, prostate, pancreatic and non-small cell cancers that transform to high-grade neuroendocrine cancers. Specifically, Dr. Roper is engaged in translational research aimed at understanding the epigenetic, immunologic and molecular aspects of neuroendocrine differentiation with the goal of translating experimental data to the clinic.

Areas of Expertise

1) high-grade neuroendocrine tumors, 2) small cell lung cancer, 3) tumor heterogeneity,
4) immunotherapy, 5) EGFR mutant non-small cell lung cancer

Contact Info

Nitin Roper, M.D., M.Sc.
Center for Cancer Research
National Cancer Institute
Building 37, Room 5056B
Bethesda, MD 20892
Ph: 240-858-3571
nitin.roper@nih.gov

My overall research goal is to decipher the mechanisms which drive the aggressive clinical behavior of high-grade neuroendocrine tumors including treatment resistance. In particular, I am interested in: 1) deciphering the biologic mechanisms of high-grade neuroendocrine tumors that may, in turn, predict response or lack of response to immune checkpoint inhibition; 2) elucidating the epigenetic mechanisms which drive recurrent, treatment refractory high-grade neuroendocrine tumors; and 3) establishing pre-clinical models of high-grade neuroendocrine tumors. These studies will inform rational combinations to augment both targeted and immunotherapy approaches within high-grade neuroendocrine tumors.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Computational Biology, Genetics and Genomics, Immunology

Selected Recent Publications

  1. Roper N, Gao S, Maity TK, Banday AR, Zhang X, Venugopalan A, Cultraro CM, Patidar R, Sindiri S, Brown AL, Goncearenco A, Panchenko AR, Biswas R, Thomas A, Rajan A, Carter CA, Kleiner DE, Hewitt SM, Khan J, Prokunina-Olsson L, Guha U.
    Cell Reports. 26(10): 2651-2666, 2019. [ Journal Article ]
  2. Thomas A, Vilimas R, Trindade C, Erwin-Cohen R, Roper N, Xi L, Krishnasamy V, Levy E, Mammen A, Nichols S, Chen Y, Velcheti V, Yin F, Szabo E, Pommier Y, Steinberg SM, Trepel JB, Raffeld M, Young HA, Khan J, Hewitt S, Lee JM.
    Journal of Thoracic Oncology. 14(8): 1447-1457, 2019. [ Journal Article ]
  3. Zhang X, Nguyen KD, Rudnick PA, Roper N, Kawaler E, Maity TK, Awasthi S, Gao S, Biswas R, Venugopalan A, Cultraro CM, Fenyö D, Guha U.
    Molecular Cellular Proteomics. 18(4): 622-641, 2019. [ Journal Article ]
  4. Teo MY, Bambury RM, Zabor EC, Jordan E, Al-Ahmadie H, Boyd ME, Bouvier N, Mullane SA, Cha EK, Roper N, Ostrovnaya I, Hyman DM, Bochner BH, Arcila ME, Solit DB, Berger MF, Bajorin DF, Bellmunt J, Iyer G, Rosenberg JE.
    Clinical Cancer Research. 23(14): 3610-3618, 2017. [ Journal Article ]

After completing his undergraduate work at Brown University, Dr. Roper received his M.D. at the University of Connecticut School of Medicine. He completed an internship and residency in internal medicine at Mount Sinai Hospital in New York City. He subsequently obtained a Master’s in Clinical Research Methods from Columbia University, Mailman School of Public Health and was an Instructor in Medicine at Weill Cornell Medical College. He recently completed medical oncology training through the NHLBI-NCI Hematology Oncology Fellowship program and is board certified in Medical Oncology. Dr. Roper joined the Developmental Therapeutics Branch as an Assistant Clinical Investigator in 2019.