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Yongjun Sui

Yongjun Sui, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Associate Scientist
Vaccine Branch

RESEARCH SUMMARY

Dr. Sui’s research focuses on the induction and maintenance of tissue resident T cells, mucosal antibody responses, and trained innate immunity in colorectal mucosa and respiratory tracts. She has optimized the synergistic effects of immune modulators and viral vectors, as well as mucosal delivery method to promote the quantity and quality of immune responses. Using rodent and non-human primate models, she has been translating these strategies into the development of mucosal vaccines, including but not limited to HIV and SARS-CoV-2.  She is also interested in identifying innate and adaptive immune correlates of protection to improve the vaccine efficacy. 
 

Areas of Expertise

Immunology
Mucosal Immunity
HIV And SARS-CoV-2 Vaccines
Resident T Cell
Trained Innate Immunity

Publications

Selected Recent Publications

Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Sui Y*, Li J, Zhang R, Prabhu SK, Elyard HA, Venzon D, Cook A, Brown RE, Teow E, Velasco J, Greenhouse J, Putmon-Taylor T, Campbell TV, Pessaint L, Moore IN, Lagenaur LA, Talton JD, Breed MW, Kramer J, Bock KW, Minai M, Nagata BM, Lewis MG, Wang LX, Berzofsky JA
* corresponding author
JCI Insight. 6/10: 2021.
Full-Text Article
[ Journal Article ]

Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response

Sui Y*, Lewis G, Wang Y, Berckmuelle K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters C, Talton J, Clements J, Tomaras G, Franchini G, Robert-Guroff M, TrinchieriG, GalloR, Berzofsky J
*corresponding author
The Journal of clinical investigation. 129/3: 1314-28, 2019.
Full-Text Article
[ Journal Article ]

Vaginal type-II mucosa is an inductive site for primary CD8(+) T-cell mucosal immunity

Wang Y, Sui Y*, Kato S, Hogg AE, Steel JC, Morris JC, Berzofsky JA
* corresponding author
Nature communications. 6:6100: 2015.
Full-Text Article
[ Journal Article ]

Vaccine-induced myeloid cell population dampens protective immunity to SIV

Sui Y*, Hogg A, Wang Y, Frey B, Yu H, Xia Z, Venzon D, McKinnon K, Smedley J, Gathuka M, Klinman D, Keele BF, Langermann S, Liu L, Franchini G, Berzofsky JA.
* corresponding author
The Journal of clinical investigation. 124: 2538-49, 2014.
Full-Text Article
[ Journal Article ]

Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques

Sui Y*, Zhu Q, Gagnon S, Dzutsev A, Terabe M, Vaccari M, Venzon D, Klinman D, Strober W, Kelsall B, Franchini G, Belyakov IM, Berzofsky JA.
* corresponding author
Proc. Natl. Acad. Sci. U.S.A.. 107: 9843-8, 2010.
Full-Text Article
[ Journal Article ]