Surgical Oncology Research and Cancer Immunotherapy Fellowships

The Fellowships in Surgical Oncology Research and Cancer Immunotherapy at the National Cancer Institute (NCI) encompass two time-honored programs combining bench-side research in surgical oncology with training in clinical research through direct patient care.  The unique environment of the Clinical Center at the National Institutes of Health (NIH) allows for direct bedside-to-bench and bench-to-bedside translational research under the direction of world leaders in surgical oncology.

Two- and three-year research programs are available.

Description of Fellowships


Surgical Oncology Research Fellowship

This 2-year fellowship includes 18 months of bench laboratory experience in one of the many NCI laboratories and 6 months of clinical rotations over three surgical oncology subspecialties. Clinical research opportunities are available over the entire 2-year period. An additional, optional research year may be available.


Fellowship in Cancer Immunotherapy

This 3-year fellowship incorporates a year of clinical experience in the management of patients undergoing cell-based cancer immunotherapy developed in the Surgery Branch of the NCI. Following that year, the fellow moves on to 18 months of bench laboratory experience in one of the multiple immunotherapy laboratories within the NCI and 6 months of clinical rotations over three surgical oncology subspecialties. This fellowship is complemented by additional didactic opportunities in cancer immunotherapy.


Fellowship Director

Andrew M. Blakely, M.D.
Fellowship Program Director


Program Administrator

Ms. Joanna Lamot
Ph: 240.858.3731

 



All CCR residents and clinical fellows train at the 240-bed NIH Clinical Center, internationally recognized as the premier hospital dedicated to translational research and clinical care. Elective rotations offer residents and clinical fellows the opportunity to have direct experience in the care of patients enrolled in investigational protocols in the disciplines allergy and immunology, anatomic pathology, critical care medicine/internal medicine, hematopathology, infectious diseases, medical genetics, and transfusion medicine. Participants will have first-hand exposure to the design, conduct, and management of clinical trials. 

All of CCR’s clinical training programs are part of Graduate Medical Education at NIH

Surgical Oncology Research Fellows 2018


How to Apply


The Surgical Oncology Fellowship commences on July 1st. Applications are accepted throughout the year. A statement of interest in the program, curriculum vitae and three (3) letters of recommendation should be sent directly to the Program Administrator.

Alternatively, interested applicants may submit materials through the NIH Graduate Medical Education page; if using this system, the applicant should contact the Program Administrator to ensure that application materials have been received.


For More Information


Please contact the Program Administrator, Joanna Lamot, for additional information.

Application materials, including CV, letters of recommendation and cover letter, may be sent directly to the Program Administrator.

View Fellowship Program Details




Fellowship Faculty


Name Position Specialty
Dr. Andrew M. Blakely

Program Director, Surgical Oncology Research Fellowship

Assistant Research Physician

Surgical Oncology
Dr. Martha A. Zeiger Director, Surgical Oncology Program Endocrine Surgery
Dr. Jeremy L. Davis

Surgeon-in-Chief

Associate Research Physician

Surgical Oncology
Dr. Jonathan M. Hernandez

Section Chief, Surgical Oncology

Investigator

Surgical Oncology
Dr. Naris Nilubol

Section Chief, Endocrine Surgery

Physician-Scientist Early Investigator

Endocrine Surgery
Dr. Samira Sadowski Physician-Scientist Early Investigator Endocrine Surgery
Dr. David S. Schrump

Chief, Thoracic Surgery Branch

Senior Investigator

Thoracic Surgery
Dr. Chuong D. Hoang Investigator Thoracic Surgery
Dr. Steven A. Rosenberg

Chief, Surgery Branch

Senior Investigator

Cancer Immunotherapy
Dr. Richard M. Sherry Associate Research Physician Cancer Immunotherapy
Dr. James C. Yang Senior Investigator Cancer Immunotherapy
Dr. Stephanie L. Goff Associate Research Physician Cancer Immunotherapy


Didactics and Clinical Research


Multiple educational conferences highlighting the principles of clinical research are integrated throughout the fellowship experience.

Surgical Oncology Fellows’ Educational Conference

Weekly lecture series throughout the academic year with presentations from NCI faculty addressing the fundamentals of clinical study design and interpretation, design and progress of current NCI clinical trials, and fellow-led debates on current questions in surgical oncology.

Weekly Clinical Conference

Weekly departmental meeting similar to Grand Rounds and Morbidity/Mortality conference focusing on management of challenging cases of the NCI Surgical Oncology Clinical Service.

Surgical Oncology Fellows’ Journal Club

Monthly, fellow-run Surgical Oncology Journal Club focusing on seminal and current studies across general, thoracic, and endocrine surgical oncology.

Surgical Oncology Clinical Research Meeting

Twice-monthly, clinical research think-tank focused on the development and support of clinical research projects for fellows.

Multidisciplinary Oncology Meetings

Multiple clinically and translationally oriented meetings focus on care of complex general surgical oncology, thoracic and endocrine diseases:

  • NIH Foregut Team manages patients with tumors of the esophagus, stomach, liver, pancreas and bile ducts
  • Thoracic Tumor Board
  • Endocrine Oncology Tumor Board

NIH-Wide Lecture and Educational Opportunities

Diverse, NIH-wide lecture series focusing on basic science, translational and clinical work as well as traditional classroom educational opportunities in basic and clinical science available through the NIH Graduate School.


Recent Alumni


Complex General Surgical Oncology

Chenwi Ambe, MD
Moffitt Cancer Center

Reed I. Ayabe, MD
NCI Fellowship: 2017-2019
Specialty Fellowship: MD Anderson Cancer Center, 2021-2023

Joal Beane, MD
Specialty Fellowship: University of Pittsburgh Medical Center, 2017-2019

Jessica Crystal, MD
Specialty Fellowship: Cedars Sinai Medical Center, 2018-2020

Jeremy L. Davis, MD
NCI Fellowship: 2007-2010
Specialty Fellowship: Memorial Sloan Kettering Cancer Center, 2013-2015

Lindy Davis, MD
Roswell Park Cancer Institute

Timothy L. Frankel, MD
Specialty Fellowship: Memorial Sloan Kettering Cancer Center, 2011-2013

Danielle Hari, MD
John Wayne Cancer Institute

Jenny Hong, MD
Specialty Fellowship: Cedars Sinai Medical Center, 2015-2017

Young Ki Hong, MD
University of Louisville

Mio Kitano, MD
The Ohio State University

Mei Li Kwong, MD
Loma Linda University

Russell C. Langan, MD
NCI Fellowship: 2009-2012
Specialty Fellowship: Memorial Sloan Kettering Cancer Center, 2015-2017

Winifred Lo, MD
NCI Fellowship: 2015-2018
Specialty Fellowship: University of Pittsburgh Medical Center, 2021-2023

John E. Mullinax, MD
Moffitt Cancer Center

Peter A. Prieto, MD
NCI Fellowship: 2009-2011
Specialty Fellowship: MD Anderson Cancer Center, 2014-2017

Luke Rothermel, MD
NCI Fellowship: 2012-2014
Specialty Fellowship: Moffitt Cancer Center, 2017-2019

Nicholas Schaub, MD
University of North Carolina, Chapel Hill

Jennifer Tseng, MD
University of Chicago

 

Cardiothoracic Surgery

Scott Atay, MD
MD Anderson Cancer Center

Paul Feingold, MD
Specialty Fellowship: Brigham and Women's, 2021-2023

Mohammad Jafferji, MD
NCI Fellowship: 2016-2019
Specialty Fellowship: Baylor College of Medicine, 2021-2024

Clinton Kemp, MD
The Johns Hopkins University

Kiran Lagisetty, MD
University of Michigan

Kaitlin C. McLoughlin, MD
NCI Fellowship: 2016-2018
Specialty Fellowship: Memorial Sloan Kettering Cancer Center, 2021-2023

R. Taylor Ripley, MD
Memorial Sloan Kettering Cancer Center

Christopher Scott, MD
Duke University

Trevor Upham, MD
University of California, San Diego

 

Breast Surgical Oncology

Kshama Jaiswal, MD
NCI Fellowship: 2007-2009
Specialty Fellowship: Memorial Sloan Kettering Cancer Center, 2010-2011

Tristen Park, MD
Duke University

Sarah Treter, MD
Yale University

 

Endocrine Surgery

Yasmine Assadipour, MD
Specialty Fellowship: University of California, Los Angeles, 2017-2018

Aarti Mathur, MD
Specialty Fellowship: The Johns Hopkins University, 2013-2014

Reza Rahbari, MD
Cleveland Clinic

Syed Shah, MD
Specialty Fellowship: Duke University, 2015-2016

Ashley Stewart, MD
MD Anderson Cancer Center

 

Hepatobiliary Surgery

Rachel Beard, MD
University of Pittsburgh Medical Center

Simon Turcotte, MD
Memorial Sloan-Kettering Cancer Center

 

Colorectal Surgery

Melissa Alvarez-Downing, MD
Cleveland Clinic, Florida

 

Pediatric Surgery

Eric Groh, MD
NCI Fellowship: 2014-2017
Specialty Fellowship: University of Indiana, 2020-2022

Lucas McDuffie, MD
NCI Fellowship: 2013-2015
Specialty Fellowship: University of Indiana, 2018-2020

Manish Raiji, MD
NCI Fellowship: 2011-2013
Specialty Fellowship: University of Chicago, 2015-2017


Fellows


Class Starting in 2019

Class Starting in 2018

Class Starting in 2017

Class Starting in 2016

Class Starting in 2015


Publications


2020

1.       PMID 32437494. Aversa JG, Diggs LP, Hagerty BL, Dominguez DA, Luu C, Hernandez JM. Trends of Clinician Adherence to Evidence-Based Recommendations for Multidisciplinary Oncology Care for Patients With Esophageal Cancer. JAMA Oncol. 2020 May 21;e201065.

2.       PMID 32422580. Aversa JG, Monroe C, Levi A, Papanicolau-Sengos A, Kleiner DE, Hernandez JM. The First Malignant Primary Hepatic Glomus Tumor: A Case Report. Int J Surg Case Rep. 2020 May 11;70:197-200.

3.       PMID 32399263. Gupta S, McDonald JD, Ayabe RI, Khan TM, Gamble LA, Sinha S, Hannah C, Blakely AM, Davis JL, Hernandez JM. Targeting CA 19-9 With a Humanized Monoclonal Antibody at the Time of Surgery May Decrease Recurrence Rates for Patients Undergoing Resections for Pancreatic Cancer, Cholangiocarcinoma and Metastatic Colorectal Cancer. J Gastrointest Oncol. 2020 Apr;11(2):231-235.

4.       PMID 32362388. Khan TM, Hoang CD. Commentary: Pigmented Spot During Esophagoscopy-A Mole or Melanoma?. J Thorac Cardiovasc Surg. 2020 Apr 13;S0022-5223(20)30785-6.

5.       PMID 32329691. Horibata S, Alyateem G, DeStefano CB, Gottesman MM. The Evolving AML Genomic Landscape: Therapeutic Implications. Curr Cancer Drug Targets. 2020 Apr 24.

6.       PMID 32228502. Aversa JG, De Abreu FB, Yano S, Xi L, Hadley DW, Manoli I, Raffeld M, Sadowski SM, Nilubol N. The First Pancreatic Neuroendocrine Tumor in Li-Fraumeni Syndrome: A Case Report. BMC Cancer. 2020 Mar 30;20(1):256.

7.       PMID 32189170. McDonald JD, Hernandez JM. ASO Author Reflections: Fibrolamellar Hepatocellular Carcinoma and Alpha-Fetoprotein. Ann Surg Oncol. 2020 Jun;27(6):1906-1907.

8.       PMID 32175112. Martin SP, Drake JA, Hernandez JM, Davis JL. Bidirectional Chemotherapy in Patients With Gastric Cancer and Peritoneal Metastasis. J Gastrointest Oncol. 2020 Feb;11(1):108-111.

9.       PMID 32000167. Malekzadeh P, Cowan K, Steinberg SM, Camphausen KA, Shriver C, Merino MJ, Good ML, Berman A, Danforth DN Jr. Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer. Am J Clin Oncol. 2020 May;43(5):334-339.

10.       PMID 31996390. Malekzadeh P, Yossef R, Cafri G, Paria BC, Lowery FJ, Jafferji M, Good ML, Sachs A, Copeland AR, Kim SP, Kivitz S, Parkhurst MR, Robbins PF, Ray S, Xi L, Raffeld M, Yu Z, Restifo NP, Somerville RPT, Rosenberg SA, Deniger DC. Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens. Clin Cancer Res. 2020 Mar 15;26(6):1267-1276.

11.       PMID 31944498. Good ML, Malekzadeh P, Kriley IR, Shah NN, Kleiner DE, Calvo K, Hernandez JM, Davis JL. Intrahepatic cholangiocarcinoma as a rare secondary malignancy after allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia: A case report. Pediatr Transplant. 2020 Mar;24(2):e13653.

12.       PMID 31941754. Zhang K, Pomyen Y, Barry AE, Martin SP, Khatib S, Knight L, Forgues M, Dominguez DA, Parhar R, Shah AP, Bodzin AS, Wang XW, Dang H. AGO2 mediates MYC mRNA stability in hepatocellular carcinoma. Mol Cancer Res. 2020 Apr;18(4):612-622.

13.       PMID 31925595. McDonald JD, Gupta S, Shindorf ML, Gamble LA, Ruff SM, Drake J, Heller T, Wan JY, Dickson PV, Glazer ES, Davis JL, Deneve JL, Hernandez JM. Elevated Serum α-Fetoprotein is Associated with Abbreviated Survival for Patients with Fibrolamellar Hepatocellular Carcinoma Who Undergo a Curative Resection. Ann Surg Oncol. 2020 Jun;27(6):1900-1905.

2019

1.       PMID 31808558. Lo W, Ayabe RI, Kariya CM, Good ML, Steinberg SM, Davis JL, Ripley RT, Hernandez JM. Stage and disease-free interval help select patients for surgical management of locally recurrent and metastatic adrenocortical carcinoma. J Surg Oncol. 2019 Dec 6.

2.       PMID 31761460. Gupta S, McDonald JD, Wach MM, Badillo AT, Steinberg SM, Davis JL, Kotagal M, Garrison AP, Hernandez JM. Qualities and Characteristics of Applicants Associated with Successful Matriculation to Pediatric Surgery Fellowship Training. J Pediatr Surg. 2019 Nov 9;S0022-3468(19)30792-4.

3.       PMID 31754337. Fako V, Martin SP, Pomyen Y, Budhu A, Chaisaingmongkol J, Franck S, Lee JM, Ng IO, Cheung TT, Wei X, Liu N, Ji J, Zhao L, Liu Z, Jia HL, Tang ZY, Qin LX, Kloeckner R, Marquardt J, Greten T, Wang XW. Gene signature predictive of hepatocellular carcinoma patient response to transarterial chemoembolization. Int J Biol Sci. 2019 Oct 3;15(12):2654-2663.

4.       PMID 31749079. Groh EM, Gupta S, Brown ZJ, Enewold L, Gamble LA, Hernandez JM, Davis JL. Staging Laparoscopy is Underutilized in the Management of Gastric Adenocarcinoma. Ann Surg Oncol. 2020 May;27(5):1473-1479.

5.       PMID 31734237. Ruff SM, Rothermel LD, Diggs LP, Wach MM, Ayabe RI, Martin SP, Boulware D, Anaya D, Davis JL, Mullinax JE, Hernandez JM. Tumor grade may be used to select patients with multifocal hepatocellular carcinoma for resection. HPB (Oxford). 2019 Nov 13;S1365-182X(19)32273-7.

6.       PMID 31710026. Good ML, Vizcardo R, Maeda T, Tamaoki N, Malekzadeh P, Kawamoto H, Restifo NP. Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells. J Vis Exp. 2019 Oct 24;(152).

7.       PMID 31671219. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan. Int J Cancer. 2019 Oct 31.

8.       PMID 31588021. Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW. Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer. Cancer Cell. 2019 Oct 14;36(4):418-430.e6.

9.       PMID 31570787. Xu Y, Surman DR, Diggs L, Xi S, Gao S, Gurusamy D, McLoughlin K, Drake J, Feingold P, Brown K, Wangsa D, Wangsa D, Zhang X, Ried T, Davis JLHernandez J, Hoang CD, Souza RF, Schrump DS, Ripley RT. Bile acid-induced "Minority MOMP" promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1. Oncogene. 2020 Jan;39(4):877-890.

10.    PMID 31531722. Good MLMalekzadeh P, Ruff SM, Gupta S, Copeland A, Pacak K, Nilubol N, Kebebew E, Patel D. Surgical Resection of Pheochromocytomas and Paragangliomas is Associated with Lower Cholesterol Levels. World J Surg. 2020 Feb;44(2):552-560.

11.    PMID 31520211. Ayabe RIHernandez JM. ASO Author Reflections: Using Big Data to Overcome the Challenges of Studying a Rare Tumor. Ann Surg Oncol. 2019 Dec;26(Suppl 3):727-728.

12.    PMID 31449236. Vizcardo R, Rafiqul Islam SM, Maeda T, Tamaoki N, Good ML, Klemen ND, Bosch-Marce M, Jia L, Kruhlak MJ, Restifo NP. A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants. J Vis Exp. 2019 Aug 9;(150).

13.    PMID 31447392. Ayabe RI, Narayan RR, Ruff SM, Wach MM, Lo W, Nierop PMH, Steinberg SM, Ripley RT, Davis JL, Koerkamp BG, D'Angelica MI, Kingham TP, Jarnagin WR, Hernandez JM. Disease-free interval and tumor functional status can be used to select patients for resection/ablation of liver metastases from adrenocortical carcinoma: insights from a multi-institutional study. HPB (Oxford). 2020 Jan;22(1):169-175.

14.    PMID 31408414. Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS. T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study. J Clin Oncol. 2019 Oct 20;37(30):2759-2768.

15.    PMID 31345777. Cerise A, Bera TK, Liu X, Wei J, Pastan I. Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer. Clin Colorectal Cancer. 2019 Sep;18(3):192-199.e1.

16.    PMID 31326265. Martin SP, Drake J, Wach MM, Ruff SM, Diggs LP, Wan JY, Good ML, Dominguez DA, Ayabe RI, Glazer ES, Dickson PV, Davis JL, Deneve JL, Hernandez JM. Resection and chemotherapy is the optimal treatment approach for patients with clinically node positive intrahepatic cholangiocarcinoma. HPB (Oxford). 2020 Jan;22(1):129-135.

17.    PMID 31243664. Wach MM, Grubbs EG, D'Angelica M, Hernandez JM. ASO Author Reflections: Complex General Surgical Oncology Fellowships: What Are Programs Looking For? Ann Surg Oncol. 2019 Sep;26(9):2682-2683.

18.    PMID 31222684. Davis JL, Ruff SM. ASO Author Reflections: A Glimpse of Complex General Surgical Oncology Practice After Fellowship. Ann Surg Oncol. 2019 Dec;26(Suppl 3):647-648.

19.    PMID 31205678. Martin SP, Wang XW. The evolving landscape of precision medicine in primary liver cancer. Hepat Oncol. 2019 Jun 4;6(2):HEP12.

20.    PMID 31183189. Ruff S, Curtin B, Quezado M, Heller T, Koh C, Steinberg SM, Connolly M, Hernandez JM, Davis JL. Evaluation of confocal endoscopic microscopy for detection of early-stage gastric cancer in hereditary diffuse gastric cancer (HDGC) syndrome. J Gastrointest Oncol. 2019 Jun;10(3):407-411.

21.    PMID 31164564. Brown ZJ, Heinrich B, Greten TF. Establishment of Orthotopic Liver Tumors by Surgical Intrahepatic Tumor Injection in Mice with Underlying Non-Alcoholic Fatty Liver Disease. Methods Protoc. 2018 Jun 4;1(2).

22.    PMID 31164343. Parkhurst MR, Robbins PF, Tran E, Prickett TD, Gartner JJ, Jia L, Ivey G, Li YF, El-Gamil M, Lalani A, Crystal JS, Sachs A, Groh E, Ray S, Ngo LT, Kivitz S, Pasetto A, Yossef R, Lowery FJ, Goff SL, Lo W, Cafri G, Deniger DC, Malekzadeh P, Ahmadzadeh M, Wunderlich JR, Somerville RPT, Rosenberg SA. Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers. Cancer Discov. 2019 Aug;9(8):1022-1035.

23.    PMID 31146085. Ruff SM, Ayabe RIMalekzadeh P, Good ML, Wach MM, Gonzales MK, Tirosh A, Nilubol N, Pacak K, Kebebew E, Patel D. MicroRNA-210 May Be a Preoperative Biomarker of Malignant Pheochromocytomas and Paragangliomas. J Surg Res. 2019 Nov;243:1-7.

24.    PMID 31114057. Diggs LP, Greten TF. The effects of platelet accumulation in fatty liver disease. Nat Rev Gastroenterol Hepatol. 2019 Jul;16(7):393-394.

25.    PMID 31102094. Ayabe RI, Wach M, Ruff S, Martin S, Diggs L, Wiemken T, Hinyard L, Davis JL, Luu C, Hernandez JM. Primary Gallbladder Neuroendocrine Tumors: Insights into a Rare Histology Using a Large National Database. Ann Surg Oncol. 2019 Oct;26(11):3577-3585.

26.    PMID 31079801. Klemen ND, Shindorf ML, Sherry RM. Role of Surgery in Combination with Immunotherapy. Surg Oncol Clin N Am. 2019 Jul;28(3):481-487.

27.    PMID 31079800. Jafferji MS, Yang JC. Adoptive T-Cell Therapy for Solid Malignancies. Surg Oncol Clin N Am. 2019 Jul;28(3):465-479.

28.    PMID 31044430. Kariya CM, Wach MM, Ruff SM, Ayabe RI, Lo WM, Torres MB, Petrick JL, McNeel TS, Davis JL, McGlynn KA, Hernandez JM. Postbiliary drainage rates of cholangitis are impacted by procedural technique for patients with supra-ampullary cholangiocarcinoma: A SEER-Medicare analysis. J Surg Oncol. 2019 Aug;120(2):249-255.

29.    PMID 31011903. Wach MM, Ayabe RI, Ruff SM, D'Angelica M, Dineen SP, Grubbs EG, Shibata D, Shirley L, Weiss MJ, Davis JLHernandez JM. A Survey of the Complex General Surgical Oncology Fellowship Programs Regarding Applicant Selection and Rank. Ann Surg Oncol. 2019 Sep;26(9):2675-2681.

30.    PMID 30927283. Brown ZJ, Greten TF, Heinrich B. Adjuvant Treatment of Hepatocellular Carcinoma: Prospect of Immunotherapy. Hepatology. 2019 Oct;70(4):1437-1442.

31.    PMID 30895496. Martin SP, Drake J, Wach MM, Ruff S, Diggs LP, Wan JY, Brown ZJ, Ayabe RI, Glazer ES, Dickson PV, Davis JL, Deneve JL, Hernandez JM. Laparoscopic Approach to Intrahepatic Cholangiocarcinoma is Associated with an Exacerbation of Inadequate Nodal Staging. Ann Surg Oncol. 2019 Jun;26(6):1851-1857.

32.    PMID 30882547. Goff SL, Morgan RA, Yang JC, Sherry RM, Robbins PF, Restifo NP, Feldman SA, Lu YC, Lu L, Zheng Z, Xi L, Epstein M, McIntyre LS, Malekzadeh P, Raffeld M, Fine HA, Rosenberg SA. Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma. J Immunother. 2019 May;42(4):126-135.

33.    PMID 30877618. Ruff SM, Ayabe RI, Wach MM, Diggs LP, Martin SP, Davis JLHernandez JM. Practice patterns of VTE chemoprophylaxis after discharge following hepatic and pancreatic resections for cancer: A survey of hepatopancreatobiliary surgeons. J Thromb Thrombolysis. 2019 Jul;48(1):119-124.

34.    PMID 30862714. Takai A, Dang H, Oishi N, Khatib S, Martin SP, Dominguez DA, Luo J, Bagni R, Wu X, Powell K, Ye QH, Jia HL, Qin LX, Chen J, Mitchell GA, Luo X, Thorgeirsson SS, Wang XW. Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma. Cancer Res. 2019 May 1;79(9):2379-2391.

35.    PMID 30833661. Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW. NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. Sci Rep. 2019 Mar 4;9(1):3369.

36.    PMID 30807846. Diggs LP, Ripley RT. Can Maximally Invasive Surgery Be Minimized? Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):310-311.

37.    PMID 30761439. Ruff S, Ilyas S, Steinberg SM, Tatalovich Z, McLaughlin SA, D'Angelica M, Raut CP, Delman KA, Hernandez JM, Davis JL. Survey of Surgical Oncology Fellowship Graduates 2005-2016: Insight into Initial Practice. Ann Surg Oncol. 2019 Jun;26(6):1622-1628.

38.    PMID 30760340. Lo WM, Kariya CM, Hernandez JM. Operative Management of Recurrent and Metastatic Adrenocortical Carcinoma: A Systematic Review. Am Surg. 2019 Jan 1;85(1):23-28.

39.    PMID 30745422. Lo W, Zhu B, Sabesan A, Wu HH, Powers A, Sorber RA, Ravichandran S, Chen I, McDuffie LA, Quadri HS, Beane JD, Calzone K, Miettinen MM, Hewitt SM, Koh C, Heller T, Wacholder S, Rudloff U. Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC). J Med Genet. 2019 Jun;56(6):370-379.

40.    PMID 30714987. Malekzadeh P, Pasetto A, Robbins PF, Parkhurst MR, Paria BC, Jia L, Gartner JJ, Hill V, Yu Z, Restifo NP, Sachs A, Tran E, Lo W, Somerville RP, Rosenberg SA, Deniger DC. Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers. J Clin Invest. 2019 Mar 1;129(3):1109-1114.

41.    PMID 30709841. Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA. Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. Cancer Immunol Res. 2019 Apr;7(4):534-543.

42.    PMID 30683863. Cafri G, Yossef R, Pasetto A, Deniger DC, Lu YC, Parkhurst M, Gartner JJ, Jia L, Ray S, Ngo LT, Jafferji M, Sachs A, Prickett T, Robbins PF, Rosenberg SA. Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients. Nat Commun. 2019 Jan 25;10(1):449.

43.    PMID 30646017. Helman SR, Stevanovic S, Campbell TE, Kwong MLM, Doran SL, Faquin WC, Hinrichs CS. Human Papillomavirus T-Cell Cross-reactivity in Cervical Cancer: Implications for Immunotherapy Clinical Trial Design. JAMA Netw Open. 2018 Jul 6;1(3):e180706.

44.    PMID 30618047. Drake J, Schreiber KC, Lopez R, Fasaye GA, Connolly M, Quezado M, Heller T, Hernandez JM, Davis JL. Establishing a center of excellence for hereditary diffuse gastric cancer syndrome. J Surg Oncol. 2019 May;119(6):673-674.

2018

1.       PMID 30518633. Stevanović S, Helman SR, Wunderlich JR, Langhan MM, Doran SL, Kwong MLM, Somerville RPT, Klebanoff CA, Kammula US, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS. A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers. Clin Cancer Res. 2019 Mar 1;25(5):1486-1493.

2.       PMID 30511132. Groh EM, Hyun N, Check D, Heller T, Ripley RTHernandez JM, Graubard BI, Davis JL. Trends in Major Gastrectomy for Cancer: Frequency and Outcomes. J Gastrointest Surg. 2019 Sep;23(9):1748-1757.

3.       PMID 30463745. Hughes MS, Lo WM, Beresnev T, Merino M, Shutack Y, Ripley RTHernandez JM, Davis JL. A Phase II Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Adrenocortical Carcinoma. J Surg Res. 2018 Dec;232:383-388.

4.       PMID 30414862. Yu SJ, Ma C, Heinrich B, Brown ZJ, Sandhu M, Zhang Q, Fu Q, Agdashian D, Rosato U, Korangy F, Greten TF. Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma. J Hepatol. 2019 Mar;70(3):449-457.

5.       PMID 30399326. McLoughlin KC, Brown ZJ, Shukla Y, Shukla V. Promise and pitfalls of immune checkpoint inhibitors in hepato-pancreato-biliary malignancies. Discov Med. 2018 Sep;26(142):85-92.

6.       PMID 30377451. Brar G, Greten TF, Brown ZJ. Current frontline approaches in the management of hepatocellular carcinoma: the evolving role of immunotherapy. Therap Adv Gastroenterol. 2018 Oct 25;11:1756284818808086.

7.       PMID 30306369. Lo WM, Patel DT. ASO Author Reflections: Parathyroid Carcinoma-Setting the Stage for Prognosis. Ann Surg Oncol. 2018 Dec;25(Suppl 3):864-865.

8.       PMID 30302193. Brown ZJ, Heinrich B, Greten TF. Development of shellfish allergy after exposure to dual immune checkpoint blockade. Hepat Oncol. 2018 Feb 9;5(1):HEP02.

9.       PMID 30143231. Wach MM, van Beek E, Ayabe R, Ruff S, Brown Z, Goldman DA, Zambirinis CP, Gholami S, Pulitzer M, Hernandez J, Coit D. Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy. Am J Surg. 2018 Nov;216(5):963-968.

10.    PMID 30139566. Martin SP, Ruff S, Diggs LP, Drake J, Ayabe RI, Brown ZJ, Wach MM, Steinberg SM, Davis JLHernandez JM. Tumor grade and sex should influence the utilization of portal lymphadenectomy for early stage intrahepatic cholangiocarcinoma. HPB (Oxford). 2019 Apr;21(4):419-424.

11.    PMID 30054823. Wach MM, Ruff SM, Ayabe RI, Martin SP, Diggs LP, Alexander IA, Steinberg SM, Davis JLHernandez JM. An Examination of Applicants and Factors Associated with Matriculation to Complex General Surgical Oncology Fellowship Training Programs. Ann Surg Oncol. 2018 Nov;25(12):3436-3442.

12.    PMID 29971678. Lo WM, Good ML, Nilubol N, Perrier ND, Patel DT. Tumor Size and Presence of Metastatic Disease at Diagnosis are Associated with Disease-Specific Survival in Parathyroid Carcinoma. Ann Surg Oncol. 2018 Sep;25(9):2535-2540.

13.    PMID 29959458. Brown ZJ, Yu SJ, Heinrich B, Ma C, Fu Q, Sandhu M, Agdashian D, Zhang Q, Korangy F, Greten TF. Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma. Cancer Immunol Immunother. 2018 Aug;67(8):1305-1315.

14.    PMID 29934340. Feingold PL, Surman DR, Brown K, Xu Y, McDuffie LA, Shukla V, Reardon ES, Crooks DR, Trepel JB, Lee S, Lee MJ, Gao S, Xi S, McLoughlin KC, Diggs LP, Beer DG, Nancarrow DJ, Neckers LM, Davis JL, Hoang CDHernandez JM, Schrump DS, Ripley RT. Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma. Mol Cancer Ther. 2018 Sep;17(9):2013-2023.

15.    PMID 29933761. Ripley RT, Surman DR, Diggs LP, Trepel JB, Lee MJ, Ryan J, Davis JL, Steinberg SM, Hernandez JM, Hoang C, Kenney CM, Bond CD, Kunst TF, Letai A, Schrump DS. Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy. BMC Gastroenterol. 2018 Jun 22;18(1):94.

16.    PMID 29904153. Brown ZJ, Heinrich B, Greten TF. Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research. Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):536-554.

17.    PMID 29853601. Deniger DC, Pasetto A, Robbins PF, Gartner JJ, Prickett TD, Paria BC, Malekzadeh P, Jia L, Yossef R, Langhan MM, Wunderlich JR, Danforth DN, Somerville RPT, Rosenberg SA. T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers. Clin Cancer Res. 2018 Nov 15;24(22):5562-5573.

18.    PMID 29795111. Brown ZJ, Fu Q, Ma C, Kruhlak M, Zhang H, Luo J, Heinrich B, Yu SJ, Zhang Q, Wilson A, Shi ZD, Swenson R, Greten TF. Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. Cell Death Dis. 2018 May 23;9(6):620.

19.    PMID 29725898. van Beek EJAH, Hernandez JM, Goldman DA, Davis JL, McLoughlin K, Ripley RT, Kim TS, Tang LH, Hechtman JF, Zheng J, Capanu M, Schultz N, Hyman DM, Ladanyi M, Berger MF, Solit DB, Janjigian YY, Strong VE. Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer. Ann Surg Oncol. 2018 Jul;25(7):2027-2033.

20.    PMID 29672342. Mehta GU, Malekzadeh P, Shelton T, White DE, Butman JA, Yang JC, Kammula US, Goff SL, Rosenberg SA, Sherry RM. Outcomes of Adoptive Cell Transfer With Tumor-infiltrating Lymphocytes for Metastatic Melanoma Patients With and Without Brain Metastases. J Immunother. 2018 Jun;41(5):241-247.

21.    PMID 29653754. McLoughlin KC, Ripley RT. Finding a needle in a haystack of needles: The difficulty of defining a consistently meaningful cytokine signature. J Thorac Cardiovasc Surg. 2018 Jun;155(6):2646-2647.

22.    PMID 29562175. Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP. Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System. Cell Rep. 2018 Mar 20;22(12):3175-3190.

23.    PMID 29555087. Diggs LP, Ripley RT. Da Vinci's ascent: Continually broadening the scope of robotic thoracic surgery. J Thorac Cardiovasc Surg. 2018 Aug;156(2):e133-e134.

24.    PMID 29468433. Li D, Lo W, Rudloff U. Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk. Clin Transl Med. 2018 Feb 22;7(1):7.

2017

1.       PMID 29397150. Diggs LP, Ripley RT. The good, the bad, and the uncertain: Can matrix metalloproteinase 12 simultaneously be protumorigenic and antitumorigenic? J Thorac Cardiovasc Surg. 2018 May;155(5):2162-2163.

2.       PMID 29317095. Ripley RT, Ayabe RI. Immunotherapy: The power of perseverance. J Thorac Cardiovasc Surg. 2018 Apr;155(4):1775-1776.

3.       PMID 29299372. Brown ZJHernandez JM, Ripley RT, Davis JL. Heated intraperitoneal chemotherapy and gastrectomy for gastric cancer in the U.S.: the time is now. J Gastrointest Oncol. 2017 Dec;8(6):1109-1113.

4.       PMID 29157287. Brown ZJ, Heinrich B, Steinberg SM, Yu SJ, Greten TF. Safety in treatment of hepatocellular carcinoma with immune checkpoint inhibitors as compared to melanoma and non-small cell lung cancer. J Immunother Cancer. 2017 Nov 21;5(1):93.

5.       PMID 29145578. Straughan DM, McLoughlin KC, Mullinax JE, Marciano BE, Freeman AF, Anderson VL, Uzel G, Azoury SC, Sorber R, Quadri HS, Malech HL, DeRavin SS, Kamal N, Koh C, Zerbe CS, Kuhns DB, Gallin JI, Heller T, Holland SM, Rudloff U. The Changing Paradigm of Management of Liver Abscesses in Chronic Granulomatous Disease. Clin Infect Dis. 2018 Apr 17;66(9):1427-1434.

6.       PMID 28935813. Shukla V, Rao M, Zhang H, Beers J, Wangsa D, Wangsa D, Buishand FO, Wang Y, Yu Z, Stevenson HS, Reardon ES, McLoughlin KC, Kaufman AS, Payabyab EC, Hong JA, Zhang M, Davis S, Edelman D, Chen G, Miettinen MM, Restifo NP, Ried T, Meltzer PA, Schrump DS. ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer. Cancer Res. 2017 Nov 15;77(22):6267-6281.

7.       PMID 28918928. McLoughlin KC, Goldin JW, Ripley RT. Biology is king and continues to rule. J Thorac Cardiovasc Surg. 2017 Oct;154(4):1448-1449.

8.       PMID 28870400. Lo WM, Ripley RT. EGFR mutational status in lung adenocarcinoma: Staging implications or continuous evolution? J Thorac Cardiovasc Surg. 2017 Nov;154(5):1766-1767.

9.       PMID 28859951. Hernandez JM, Brown ZJ, D'Angelica MI. A palpable pancreatic duct. Surgery. 2017 Dec;162(6):1340-1342.

10.    PMID 28713680. McLoughlin KC, Kaufman AS, Schrump DS. Targeting the epigenome in malignant pleural mesothelioma. Transl Lung Cancer Res. 2017 Jun;6(3):350-365.

11.    PMID 28461055. McLoughlin KC, Ripley RT. Looks aren't everything, but neither is microRNA profiling. J Thorac Cardiovasc Surg. 2017 Aug;154(2):728-729.

12.    PMID 27939030. McLoughlin KC, Ripley RT. Clinical nomograms: Is a picture worth a thousand words? J Thorac Cardiovasc Surg. 2017 Feb;153(2):470-471.

  • Fellow with scientific poster
  • Surgical Team in the OR
  • The OR setup with equipment
  • Patient's Eye View of the Surgical Team
  • Dr.  Davis with a fellow in the OR.
  • Meeting in a board room.
  • Samantha Ruff with a scientific poster
  • Dr. Davis with fellows at the Society of Surgical Oncology 2018 Annual Cancer Symposium
  • Fellows group photo in lab coats