Surajit Sinha, Ph.D.

Surajit Sinha, Ph.D.
Research Fellow

Team Member of:

Dr. Sinha is interested in the global reprogramming events, both at the molecular and proteomic levels, that drive tumor cell dissemination, dormancy and metastatic outgrowth.

Areas of Expertise

1) biotechnology, 2) bioinformatics

Contact Info

Surajit Sinha, Ph.D.
Center for Cancer Research
National Cancer Institute
Bldg. 10-CRC; Rm. 4-3940
Bethesda, MD 20814
Ph: 240-858-3717
surajit.sinha@nih.gov

Dr. Sinha’s interest is in global reprogramming events both at molecular and proteomic levels that drive tumor cell dissemination, dormancy and metastatic outgrowth. Dr. Sinha utilizes bioinformatic approaches and the lab’s gain-or-loss of function genetic screens to identify genes and upstream signaling events that dictate dormancy and metastatic reactivation of disseminated tumor cells. The long-term goal is to understand molecular and proteomic programs that dictate tumor cell phenotype, and develop targeted therapies that can induce perpetual dormancy in metastasis-initiating-cells (MICs).

Selected Publications

  1. Hua Gao, Goutam Chakraborty, Zhanguo Zhang, Intissar Akalay, Mayur Gadiya, Yaquan Gao, Surajit Sinha, Jian Hu, Cizhong Jiang, Muzaffar Akram, Edi Brogi, Birit Leitinger, and Gilippo G. Giancotti
    Cell. 166: 47-62, 2016. [ Journal Article ]
  2. Tomoyo Okada, Surajit Sinha, Ilaria Esposito, Gaia Schiavon, Miguel Lopez-Lago, Wenjing Su, Christine A. Pratilas, Cristina Abele, Jonathan Hernandez, Masahiro Ohara, Morihito Okada, Agnes Viale, Nick Socci, Anna Sapino, Venkatraman E. Seshan, Stephen Long, Giorgio Inghirami, Neal Rosen, and Filippo G. Giancotti
    Nat Cell Biol. 17(1): 81-94, 2015. [ Journal Article ]
  3. Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S
    EMBO J. 29(4): 830-842, 2010. [ Journal Article ]
  4. Malonia SK, Yadav B, Sinha S, Lazennec G, Chattopadhyay S.
    Int J Biochem Cell Biol. 55: 220-226, 2014. [ Journal Article ]
  5. Sinha S, Malonia SK, Mittal SP, Mathai J, Pal JK, Chattopadhyay S.
    Int J Biochem Cell Biol. 44(1): 46-52, 2012. [ Journal Article ]

Dr. Sinha received his Ph.D. in 2010 in biotechnology with specialization in molecular cancer research from National Center for Cell Science (NCCS), one of India’s top-rated premier research institutes. He joined Memorial Sloan Kettering Cancer Center as a postdoc in 2011, and trained under the guidance of Prof. Filippo Giancotti. Dr. Sinha’s scholarly work earned him the prestigious American Association for Advancement of Science (AAAS) sponsored membership for three years. Dr. Sinha serves as an editorial board member and peer-reviewer for several biological journals.