Yungping (Jeffrey) Chiang, Ph.D.

Yungping (Jeffrey) Chiang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


One area of Dr. Chiang's research has been focused on studies of Cbl family proteins and their functions in T cell development and activation by using mouse genetic approaches. Three Cbl members have been identified as c-Cbl (Cbl), Cbl-b and Cbl-3 (Cbl-c) in mammalian cells. Cbl proteins consist of multiple functional domains, including an N-terminal tyrosine-kinase binding (TKB) domain, a ring finger (RF), a proline-rich region (PRO), and a C-terminal leucine-zipper/UBA domain. They interact with multiple protein molecules to influence signaling events via their protein-protein interaction domains. Cbl and Cbl-b proteins have been found to be critical factors in negatively mediating TCR signaling, which he is interested in. Dr. Chiang is also interested in the roles of telomeres in cancer and aging biology

Areas of Expertise

Mouse Genetics


Selected Publications

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas

Chiang YJ, Difilippantonio MJ, Tessarollo L, Morse HC, Hodes RJ.
PLoS ONE. 7: e49305, 2012. [ Journal Article ]

Cbl enforces Vav1 dependence and a restricted pathway of T cell development

Chiang J, Hodes RJ.
PLoS ONE. 6: e18542, 2011. [ Journal Article ]

Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy

Martiniova L, Lu J, Chiang J, Bernardo M, Lonser R, Zhuang Z, Pacak K.
PLoS ONE. 6: e14678, 2011. [ Journal Article ]

Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances

Padilla-Nash HM, Hathcock K, McNeil NE, Mack D, Hoeppner D, Ravin R, Knutsen T, Yonescu R, Wangsa D, Dorritie K, Barenboim L, Hu Y, Ried T.
Genes Chromosomes Cancer. 51: 353-74, 2012. [ Journal Article ]