Yongjun Sui

Yongjun Sui, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Vaccine Branch


Dr. Sui's research focuses on the development of mucosal HIV and SARS-CoV-2 vaccine using non-human primate and rodent models. She is interested in identifying innate and adaptive immune correlates of protection against HIV and SARS-CoV-2 infections, as well as exploring trained innate immunity mediated by myeloid cells.  

Areas of Expertise

1) immunology  2) virology  3) myeloid-derived suppressor cells  4) innate immunity  5) adaptive immunity 6) trained innate immunity


Selected Recent Publications

Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Sui Y, Li J, Zhang R, Prabhu SK, Elyard HA, Venzon D, Cook A, Brown RE, Teow E, Velasco J, Greenhouse J, Putmon-Taylor T, Campbell TV, Pessaint L, Moore IN, Lagenaur LA, Talton JD, Breed MW, Kramer J, Bock KW, Minai M, Nagata BM, Lewis MG, Wang LX, Berzofsky JA
JCI Insight. 6/10: 2021.
Full-Text Article
[ Journal Article ]

Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response

Sui Y, Lewis G, Wang Y, Berckmuelle K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters C, Talton J, Clements J, Tomaras G, Franchini G, Robert-Guroff M, TrinchieriG, GalloR, Berzofsky J
The Journal of clinical investigation. 129/3: 1314-28, 2019.
Full-Text Article
[ Journal Article ]

Vaccine-induced myeloid cell population dampens protective immunity to SIV

Sui Y, Hogg A, Wang Y, Frey B, Yu H, Xia Z, Venzon D, McKinnon K, Smedley J, Gathuka M, Klinman D, Keele BF, Langermann S, Liu L, Franchini G, Berzofsky JA.
J. Clin. Invest.. 124: 2538-49, 2014.
Full-Text Article
[ Journal Article ]

Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques

Sui Y, Zhu Q, Gagnon S, Dzutsev A, Terabe M, Vaccari M, Venzon D, Klinman D, Strober W, Kelsall B, Franchini G, Belyakov IM, Berzofsky JA.
Proc. Natl. Acad. Sci. U.S.A.. 107: 9843-8, 2010.
Full-Text Article
[ Journal Article ]

Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitis

Sui Y, Potula R, Dhillon N, Pinson D, Li S, Nath A, Anderson C, Turchan J, Kolson D, Narayan O, Buch S.
Am. J. Pathol.. 164: 1557-66, 2004.
Full-Text Article
[ Journal Article ]