Yan Lin Yu, Ph.D.

Yan Lin Yu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 37, Room 5046
  • Bethesda, MD 20852
  • 240-760-6812


Dr. Yu's primary research interest lies in the molecular mechanisms involved in the genesis and progression to the metastatic state of cancer. His goal is to identify candidate molecular targets or signaling pathways for mechanistic understanding, clinical diagnosis, therapeutic intervention, and cancer prevention. Since 2024, he has joined the Antibody Engineering Program at the Laboratory of Molecular Biology, focusing on the characterization of tumor antigens for antibody discovery and the development of antibody-based therapy for solid tumors, collaborating with intramural laboratories.

Areas of Expertise

Tumor Metastasis
Mouse Models
Tumor Immunology
Metastatic Melanoma and Rhabdomyosarcoma
Cancer Targets
Antibody Therapy


Selected Publications

PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

Yanlin Yu,1,7,∗ Meng Dai,2 Liping Huang,1,2 Weiping Chen,3 Ellen Yu,1 Arnulfo Mendoza,4 Helen Michael,1 Chand Khanna,4 Marcus Bosenberg,5 Martin McMahon,6 and Glenn Merlino1
iScience. 26(2): 2023.
Full-Text Article
[ Journal Article ]

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN

Yifei Qin 1, Qiang Zuo 1 2, Lei Huang 1, Liping Huang 1, Glenn Merlino 1, Yanlin Yu 3
NPJ Precis Oncol .. 5(1):68: 2021.
Full-Text Article
[ Journal Article ]

AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma

Zuo Q, Liu J, Huang L1,2, Qin Y, Hawley T, Seo C, Merlino G, Yu Y.
Oncogene. Jun;37(24): 3275-3289, 2018. [ Journal Article ]

PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation

Yu Y, Dai M, Lu A, Yu E, Merlino G.
Oncogene. Apr;37(17): 2225-2236, 2018. [ Journal Article ]

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Nat Med. 10: 175-81, 2004. [ Journal Article ]