William J. Moore, Ph.D.

Dr. Moore is a veteran of the United States Army and served in the 82^nd Airborne Division, 1/508^th Infantry Regiment.  Following his service, he received an undergraduate degree from Indiana University Southeast and then moved across the river to the University of Louisville to obtain his Ph.D. from the chemistry department with Prof. Frederick Luzzio.  He then moved to Indiana University, Bloomington, as a post-doctoral fellow working with Prof. Theodore Widlanski. He entered the public sector with a position at ArQule, Inc. located in Medford MA, a solution phase parallel synthesis CRO working with Biotech and Pharma collaborators.  After 5 years, he made a move to the pharmaceutical industry, working at Wyeth Pharmaceuticals and then Pfizer working on numerous drug discovery projects spanning several therapeutic areas such as Women’s Health, Oncology, Inflammation, Musculoskeletal Biology, Cardiovascular Disease, and Neuroscience.  In 2011, he accepted a position with Leidos Biomedical at the Frederick National Lab for Cancer Research applying his experience in medicinal chemistry and drug discovery to support the National Cancer Institute’s Experimental Therapeutics (NExT) program facilitating the strategic alignment and collaboration of government, contract research organizations and academic institutions to benefit oncology focused drug discovery programs.  He joined the CCR Chemical Biology Labs in June, 2022 as a project leader for the Medicinal Chemistry Accelerator.

Through his experience working in drug discovery, he has gained exposure to multiple drug (or undruggable) target classes such as Kinases, p97 ATPase, Protein-protein interactions (sFRP-1, Bcl family, WDR5, MLL), Metabolic (LDH, IDH), Nuclear Hormone Receptors (AR, ER), GPCR’s (Vasopressin, mGluR), and Ion Channels (Ca2+), and targeted protein degradation.